【摘 要】目的：分析老年慢性阻塞性肺病患者运用加替沙星体内的茶碱群体药代学。方法：选我院18例老年慢性阻塞性肺病患者，在加替沙星治疗前后进行血液的采样，并检测茶碱群体药代学。结果：患者用药前血液当中茶碱的浓度及茶碱的峰值低于加替沙星联合治疗后血液当中茶碱的浓度及茶碱的峰值，P<0.05。结论：对患有老年慢性阻塞性肺病患者运用加替沙星进行治疗会对血液中的茶碱产生显著的影响，药师应密切关注。

    【关键词】老年慢性阻塞性肺病;加替沙星;茶碱;药代动力学

    Abstract：Objective To analyze the pharmacokinetics of theophylline in gatifloxacin in elderly patients with chronic obstructive pulmonary disease. Methods Eighteen elderly patients with chronic obstructive pulmonary disease were enrolled in our hospital. Blood samples were taken before and after gatifloxacin treatment， and the pharmacokinetics of theophylline group was detected. Results The concentration of theophylline and the peak of theophylline in the blood before the treatment were lower than the concentration of theophylline in the blood and the peak of theophylline after the treatment with gatifloxacin ...... 婵″倹鐏夐幃銊ユ躬娴ｈ法鏁ら幍瀣簚缁涘绁︾憴鍫熸閺冪姵纭堕弻銉ф箙閹存牔绗呮潪钘夊弿閺傚浄绱濋崣顖濆厴閺勵垵顫﹂幖婊呭偍瀵洘鎼告径杈╂埂閳ユ粏娴嗛惍浣测偓婵撶礉鐠囬鍋ｉ崙璇茬潌楠炴洘娓舵稉瀣煙閻ㄥ嫧鈧粎鏁搁懘鎴犲閳ユ繃鍨ㄩ垾婊冨斧缂冩垿銆夐垾婵婎問闂傤喓鈧拷


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