支原体肺炎患儿血清PCT、sTREM-1、SPA、sICAM-1水平及其临床意义(1)
【摘 要】目的：研究支原体肺炎(MP)患儿血清降钙素原(PCT)、可溶性髓细胞触发体-1(sTREM-1)、肺表面活性蛋白A(SPA)、可溶性细胞间黏附分子-1(sICAM-1)水平及其临床意义。方法：选择我院2018年1月至2019年12月接诊的MP患儿(A组)、非MP患儿(B组)、健康体检儿童(C组)各50例作为研究对象，比较三组PCT、sTREM-1、SPA、sICAM-1水平，以及A组患儿治疗前后的PCT、sTREM-1、SPA、sICAM-1水平。结果：A组、B组PCT、sTREM-1、SPA、sICAM-1水平均高于C组，A组PCT、sTREM-1、SPA、sICAM-1水平均低于B组，差异统计学意义(P<0.05)。治疗后，A组PCT、sTREM-1、SPA、sICAM-1水平均低于治疗前，差异统计学意义(P<0.05)。结论：MP患儿的PCT、sTREM-1、SPA、sICAM-1水平高于健康体检儿童，同时低于非MP患儿，经治疗后以上各指标水平明显下降，可作为诊断MP的主要指标。
【关键词】支原体肺炎;血清降钙素原;可溶性髓细胞触发体-1;肺表面活性蛋白A;可溶性细胞间黏附分子-1
, http://www.100md.com
Abstract：Objective To study the serum levels of procalcitonin (PCT)， soluble myeloid triggering substance-1 (sTREM-1)， pulmonary surfactant A (SPA)， and soluble intercellular adhesion molecule-1 in children with mycoplasma pneumonia (MP). (SICAM-1) level and its clinical significance. Methods A total of 50 cases of MP children (group A)， non-MP children (group B)， and healthy children (group C) who were admitted to our hospital from January 2018 to December 2019 were selected as the research objects， and the three groups were compared. PCT， sTREM-1， SPA， sICAM-1 levels， and PCT， sTREM-1， SPA， sICAM-1 levels before and after treatment in children in group A. Results The levels of PCT， sTREM-1， SPA， and sICAM-1 in group A and B were higher than those in group C. The levels of PCT， sTREM-1， SPA， and sICAM-1 in group A were lower than those in group B， and the difference was statistically significant (P <0.05). After treatment， the levels of PCT， sTREM-1， SPA， and sICAM-1 in group A were lower than before treatment， and the differences were statistically significant (P <0.05). Conclusion The levels of PCT， sTREM-1， SPA， and sICAM-1 in children with MP are higher than those in healthy children and lower than those in non-MP children. The levels of the above indicators are significantly reduced after treatment， which can be used as the main indicators for diagnosis of MP.
, 百拇医药
支原体肺炎(Mycoplasma pneumonia，MP)属于一种急性的肺部炎症，病原是肺炎支原体，MP好发于儿童群体，临床表现主要为发热和干咳，该疾病能够经直接接触和飞沫进行传播，大多数患儿经治疗的预后良好，部分会发展为重症肺炎[1]。病原体抗体检测和微生物培养成为诊断和治疗MP的主要参考依据。MP患儿检测降钙素原(Procalcitonin，PCT)、可溶性髓細胞触发体-1(soluble form of triggering receptors expressed on myeloid cell，sTREM-1)、肺表面活性蛋白A(Pulmonary surfactant protein A，SPA)、可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1， sICAM-1)水平具有重要诊断价值[2]。本研究探讨MP患儿PCT、sTREM-1、SPA、sICAM-1水平及其临床意义，报道如下。
1 材料与方法
, http://www.100md.com
1.1 一般资料
选择我院2018年1月至2019年12月接诊的MP患儿(A组)、非MP患儿(B组)、健康体检儿童(C组)各50例作为研究对象。纳入标准：①A组符合MP的诊断标准[3]。②B组除MP外的肺炎。③患儿和家属均知情本研究且签署同意书。排除标准：①存在先天性疾病者。②细菌感染者。③免疫缺陷者。④C组近2个月内存在其他的基础疾病者。A 组男性24例，女性26例;年龄2～13岁，平均(5.61±0.52)岁;临床表现：喘息15例，发热12例，咳嗽35例。B组男性22例，女22例;年龄2～12岁，平均(5.72±0.42)岁。C组男性26例，女性24例;年龄2～14岁，平均(5.75±0.43)岁。三组一般资料经比较，差异无统计学意义(P>0.05)，有可比性。, 百拇医药(梁敏)
【关键词】支原体肺炎;血清降钙素原;可溶性髓细胞触发体-1;肺表面活性蛋白A;可溶性细胞间黏附分子-1
, http://www.100md.com
Abstract：Objective To study the serum levels of procalcitonin (PCT)， soluble myeloid triggering substance-1 (sTREM-1)， pulmonary surfactant A (SPA)， and soluble intercellular adhesion molecule-1 in children with mycoplasma pneumonia (MP). (SICAM-1) level and its clinical significance. Methods A total of 50 cases of MP children (group A)， non-MP children (group B)， and healthy children (group C) who were admitted to our hospital from January 2018 to December 2019 were selected as the research objects， and the three groups were compared. PCT， sTREM-1， SPA， sICAM-1 levels， and PCT， sTREM-1， SPA， sICAM-1 levels before and after treatment in children in group A. Results The levels of PCT， sTREM-1， SPA， and sICAM-1 in group A and B were higher than those in group C. The levels of PCT， sTREM-1， SPA， and sICAM-1 in group A were lower than those in group B， and the difference was statistically significant (P <0.05). After treatment， the levels of PCT， sTREM-1， SPA， and sICAM-1 in group A were lower than before treatment， and the differences were statistically significant (P <0.05). Conclusion The levels of PCT， sTREM-1， SPA， and sICAM-1 in children with MP are higher than those in healthy children and lower than those in non-MP children. The levels of the above indicators are significantly reduced after treatment， which can be used as the main indicators for diagnosis of MP.
, 百拇医药
支原体肺炎(Mycoplasma pneumonia，MP)属于一种急性的肺部炎症，病原是肺炎支原体，MP好发于儿童群体，临床表现主要为发热和干咳，该疾病能够经直接接触和飞沫进行传播，大多数患儿经治疗的预后良好，部分会发展为重症肺炎[1]。病原体抗体检测和微生物培养成为诊断和治疗MP的主要参考依据。MP患儿检测降钙素原(Procalcitonin，PCT)、可溶性髓細胞触发体-1(soluble form of triggering receptors expressed on myeloid cell，sTREM-1)、肺表面活性蛋白A(Pulmonary surfactant protein A，SPA)、可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1， sICAM-1)水平具有重要诊断价值[2]。本研究探讨MP患儿PCT、sTREM-1、SPA、sICAM-1水平及其临床意义，报道如下。
1 材料与方法
, http://www.100md.com
1.1 一般资料
选择我院2018年1月至2019年12月接诊的MP患儿(A组)、非MP患儿(B组)、健康体检儿童(C组)各50例作为研究对象。纳入标准：①A组符合MP的诊断标准[3]。②B组除MP外的肺炎。③患儿和家属均知情本研究且签署同意书。排除标准：①存在先天性疾病者。②细菌感染者。③免疫缺陷者。④C组近2个月内存在其他的基础疾病者。A 组男性24例，女性26例;年龄2～13岁，平均(5.61±0.52)岁;临床表现：喘息15例，发热12例，咳嗽35例。B组男性22例，女22例;年龄2～12岁，平均(5.72±0.42)岁。C组男性26例，女性24例;年龄2～14岁，平均(5.75±0.43)岁。三组一般资料经比较，差异无统计学意义(P>0.05)，有可比性。, 百拇医药(梁敏)