克拉霉素联合雷尼替丁治疗痤疮117例疗效观察(1)
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【摘要】目的 观察克拉霉素联合雷尼替丁治疗痤疮的临床效果，提高痤疮的治疗效果。方法 选取我院自2007年3月~2010年8月采用克拉霉素联合雷尼替丁治疗的117例寻常痤疮患者作为观察组，选取同期采用四环素联合螺内酯治疗的100例寻常痤疮患者作为对照组，两组患者均以连续治疗2周为1个疗程，连续治疗4个疗程后比较治疗效果。结果 (1)观察组显效68例，有效45例，无效14例，显效率为58.1%，总有效率为88.0%；对照组显效37例，有效50例，无效13例，显效率为37.0%，总有效率为87.0%。两组患者总有效率比较差异不大，但显效率具有显著性差异(P<0.01)，具有统计学意义。(2)观察组患者出现胃灼热感1例，恶心1例；对照组出现恶心呕吐3例，腹泻2例，腹胀2例。两组患者比较差异显著(P<0.01)，具有统计学意义。结论 克拉霉素联合雷尼替丁治疗痤疮效果理想，且不良反应较少，值得临床推广应用。
【关键词】痤疮 克拉霉素 雷尼替丁 疗效
中图分类号：R758.733 文献标识码：A 文章编号：1005-0515(2011)7-039-02
【Abstract】Objective To observe the clarithromycin combined effect of ranitidine clinical treatment of acne and improve acne treatment. Methods In our hospital from March 2007 - August 2010 using clarithromycin combined treatment of 117 cases of ranitidine in patients with acne vulgaris as a study group, select the same period the use of tetracycline combined spironolactone treatment of 100 patients with acne vulgaris patients as a control group, two groups of patients are in continuous treatment for 2 weeks as a course of treatment, continuous treatment for 4 months after treatment compared treatment. Results (1) observation group that were 68 cases, effective in 45 cases, ineffective in 14 cases, markedly effective rate was 58.1%, total effective rate was 88.0%; the control group that were 37 cases, effective 50 cases, ineffective in 13 cases, markedly effective rate was 37.0 %, total effective rate was 87.0%. Two groups of patients the difference is not always efficient, but efficiency was a significant difference (P <0.01), with statistical significance. (2) observed in patients with heartburn group 1 case of nausea in 1 case; control group had nausea and vomiting in 3 cases, 2 cases of diarrhea, abdominal distension in 2 cases. Significant difference between two groups of patients (P <0.01), with statistical significance. Conclusion Clarithromycin combined effect of ranitidine treatment of acne ideal, and fewer adverse reactions, is worthy of clinical application.
【Key words】acne clarithromycin ranitidine effect
寻常痤疮(acne vulgaris)是青年或中年人常见的一种慢性皮肤病，该病通常只发生于面部 ......
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