替米沙坦和缬沙坦治疗原发性高血压的疗效比较(1)
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【摘要】目的 比较替米沙坦和缬沙坦对轻中度原发性高血压的降压疗效及安全性。方法 150例轻中度原发性高血压患者随机分成两组各75例，替米沙坦组40 mg/d，缬沙坦组80 mg/d，早餐后顿服，疗程均8周。治疗前、后均进行血压、心率、血尿常规、肝肾功能、血生化、ECG及不良反应等检测。结果 两组均能有效降低血压(P<0.01)，替米沙坦组总有效率为94.67%，缬沙坦组总有效率为89.33%，二者差别无统计学意义(P>0.05)。两组治疗期间均未见明显不良反应。结论 替米沙坦和缬沙坦治疗轻中度高血压具有良好的降压效果，安全可靠，耐受性好,不良反应轻微。二者降低收缩压，差别无统计学意义(P>0.05)。但替米沙坦降低舒张压、降脂优于缬沙坦，且半衰期(18～24 h)更长，价格更低廉。
【关键词】原发性高血压 替米沙坦 缬沙坦 不良反应
中图分类号：R544.11文献标识码：B文章编号：1005-0515(2011)12-281-02
Comparison of telmisartan and losartan in treatment of for patients with essential hypertension
【Abstract】Objective To discuss the clinical effect and safety issues of Telmisartan and Valsartan Dispersible Tablet in curing light and to moderate essential hypertension patients. Methods The 150 light or moderate essential hypertension patients were divided into two groups randomly：75 cases in telmisartan group(40mg qd)and 75 patients in Valsartan group(80mg qd). The courses of treatment of each group were 8 weeks. The medicine was taken by patients after breakfast everyday. Data of blood pressure, heart rhythm, blood and urine routine test, hepatic and renal function, blood biochemistry test, ECG and side effects was recorded everyday before and after the treatment. Results Blood pressure were significantly reduced in both groups after treatment(P<0.01).The total anti-hypertensive effective rate was 94.67% in telmisartan group,more than 89.33% in Valsartan group (P>0.05). There was no obvious side effects in courses of treatment of 2 groups. Conclusion Both the telmisartan and Valsartan were effective medicines in curing light and moderate essential hypertension patients. These two medicines which were reliable and safety,had good tolerance and few side effects. There was no difference in decreasing systolic pressure in 2 groups(P>0.05).However, telmisartan had better effects than Valsartan in reducing diastolic blood pressure and triglyceride on light or moderate essential hypertension patients. Also, telmisartan had longer half-life period(18～24h) and lower price.
【Key words】Essential hypertension Telsartan Tablet Valsartan Dispersible Tablet side effects
原发性高血压是一种严重危害中老年人健康的常见疾病，大量的循证医学证明，高血压是引发心、脑、肾血管并发症最重要、最直接的原因。持续平稳地控制血压达正常目标水平，对延缓和阻止靶器官损害，减少猝死、脑卒中和心脏病发作，有着重要意义。
血管紧张素Ⅱ(ATⅡ)受体拮抗剂在高血压、心力衰竭等的治疗中发挥重要作用 ......
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