COX—2抑制剂联合镇痛泵对髋关节置换围手术期的疗效观察(1)
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[摘要] 目的探讨并分析COX—2抑制剂联合镇痛泵对关节置换围手术期的疗效。方法 按随机数字表法分为2组,塞来昔常规治疗组15例,其他镇痛药治疗组15例,观察并记录2组的性别、年龄、体重、手术时间、麻醉方法、疼痛的评分、生活质量评分用药量、伤口愈合情况、副反应等。结果 两组患者平均年龄、平均体重比较,差异无统计学意义(P>0.05);关节积液2组差异无统计学意义(P>0.05);2组减少镇痛泵药物使用量差异有统计学意义(P<0.05);疼痛的VAS值评分,差异有统计学意义(P<0.05);组的恶心、呕吐评分差异有统计学意义(P<0.05);生活质量评分,差异有统计学意义(P<0.05)。结论 COX—2特异性抑制剂合镇痛泵对术后疼痛的质量有明显的镇痛作用,有效性和安全性较可靠,值得临床使用和推广。
[关键词] COX—2抑制剂;镇痛泵;关节置换手术
[中图分类号] R612 [文献标识码] A[文章编号]
COX—2 inhibitor for joint pain pump hip replacement Perioperative Clinical Observation.Huang yue jun,Xiao ming People’s hospital of Qing bai jiang the ChengDu SiChuan(610300)
[Abstract] Objective Discussion and Analysis of the curative effect of COX—2 inhibitor joint the pain pump to joint replacement Perioperative; Methods Were randomly divided into 2 groups,celecoxib conventional eatment group of 15 cases of the other analgesics in the treatment gro 15 cases,2 to observe and record the group’s sex,age,weight,surgery time,anesthesia,pain score,The quality of life score, mediction,wound healing,such as side effects;Results The average age of the two grpups of patients,compared with an average body weigt there was no significant difference(P>0.05);joint fluid group 2 was no significant difference(P>0.05);2 Group Drugs analgesia reduce the use of statistical differernce Sianificance(P<0.05);value of the VAS pain score,the difference was statistically significant(P<0.05);2 group of nausea,vomiting score significantly(P<0.05);the quality of life score,the statistical difference Significance(P<0.05).Conclusion COX—2 specific inhibitors on joint pain pump for the treatment of postoperative pain has obvious analgesic effect,the ficacy and safety of the more reliable and worthy of clinical use and promotion.
[Key words]COX—2 inhibitorsAnalgesia pumpJoint replacement surgery
疼痛是需要检测的第五生命体征,术后疼痛不仅影响各种生理功能,并且对手术结局也有不良影响。同时随着人民对生活质量以及医疗质量的要求不断提高,对术中与术后无痛的要求越来越高。但是,目前临床上术后常用的非内固醇类抗炎药(NSAID)产生的副作用较多。COX—2特异性抑制剂(塞来昔布是其代表药物)目前已在欧美广泛应用于临床治疗类风湿性关节炎患者和骨关节炎患者的慢性疼痛以及手术后的镇痛[1]。本组将通过随机对照临床试验评价COX—2特异性抑制剂联合镇痛泵对术后疼痛治疗的有效性和安全性。
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