硝苯地平对小白鼠胃排空和小肠推进运动的影响(1)
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[摘要] 目的 观察硝苯地平对小白鼠胃肠运动的影响。方法 40只小白鼠,随机分为生理盐水组、阿托品组、硝苯地平Ⅰ组和硝苯地平Ⅱ组共4组,分别用生理盐水、阿托品、硝苯地平来灌胃,每只小白鼠灌胃总容量为0.8ml。阿托品用量为0.003 mg/g小白鼠体重,硝苯地平用量分别为0.0026mg、0.0052mg/g小白鼠体重,然后加生理盐水到0.8ml。每只小白鼠灌胃后,分别测量胃内残留率和小肠推进率。结果 与生理盐水组比,使用阿托品、硝苯地平后,小白鼠的胃内残留率增高(68.75±8.84%,66.25±8.44%,62.50±8.33%,p<0.05);小肠推进率减慢(42.87±9.70%,48.12±9.27% ,45.23±9.03%,p<0.01)。但硝苯地平与阿托品,及硝苯地平两组间的胃内残留率和小肠推进率差异无统计学意义。结论 硝苯地平可抑制小白鼠胃肠的运动。
[关键词] 硝苯地平;阿托品;胃内残留率;小肠推进率
[中图分类号] R976[文献标识码] A[文章编号]
The effect of nifedipine on gastric emptying and small intestine propulsive motility in mice
Zhu Xue-li1,Peng La-juan1,Zhang Ya1 , He Xian-jiao2, Huan Yan-feng2,Zhao Shan-min2
1. Nursing Specialty, UndergraduateofGrade2007, YoujiangmedicalCollegefor Nationalities, Baise , Guangxi533000,China.
2. Department ofPhysiologyofYoujiangmedicalCollegeforNationalities, Baise , Guangxi 533000, China.
[Abstract]ObjectiveTo observe the effect of nifedipine on gastrointestinal motion in mice Methods 40 mice were randomly divided into 4 groups, that is normal saline group, atropine group, nifedipine groupⅠand nifedipine groupⅡ, and respectively give normal saline, atropine, nifedipine by gavage. Each mouse was given 0.8ml in total. The dose of atropine is 0.003mg per body weight of the mouse, and that of nifedipine is 0.0026mg and 0.0052mg respectively, then add normal saline to 0.8ml. After intragastric gavage, measure gastric remnant rate and intestinal propulsive rate.ResultsCompared with normal saline group, after given atropine and nifedipine, the mice gastric remnant rate rose(68.75±8.84%,66.25±8.44%,62.50±8.33%,p<0.05)
and the intestinal propulsive rate decreased(42.87±9.70%,48.12±9.27% ,45.23±9.03%,p<0.01). However, the differences of gastric remnant rate and intestinal propulsive rate between nifedipine and atropine as well as two nifedipine groups were not statistically significant. ConclusionNifedipine can inhibit gastrointestinal motion in mice.
[Key words] nifedipine,atropine, gastric remnant rate, intestinal propulsive rate
硝苯地平是第一代的钙离子通道阻断剂,疗效稳定,药物依赖性较弱,对心脏毒性小,不良反应少,费用又低,因此被广泛应用于冠心病、高血压等心血管疾病方面的治疗。目前随着对硝苯地平的认识深入,也被应用于治疗肾和输尿管绞痛、泌尿结石、早产、胆绞痛、支气管哮喘、咯血、耳鸣等非心血管系统方面的疾病[1] ......
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