低氧对小鼠C-myc癌基因和血管内皮生长因子表达的影响(2)
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在本研究结果中,C-myc与VEGF、MVD之间均呈显著正相关,这与以上报道结果一致,表明C-myc癌基因对低氧致小鼠肺组织血管新生中的重要作用。随着分子生物学技术的发展,人们已经认识到C-myc癌基因在肿瘤血管新生中所起的重要作用,相信随着这方面研究的不断深入,在不远的将来,以缺氧和C-myc为靶点的抗肿瘤治疗必将有更大的突破。
参考文献
[1]Mizukami Y, Fujiki K,Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J Biol Chem. 2006 May 19;281(20):13957-63
[2] Weidner N. Intratumoral microvessel densityasa prognosic factor incancer [J]. AmJ Pathol , 1995,147(1):9-19
[3] NeufeldJ,CohenT,GengrinovitchS,etal.Vascular endothe lia growth factor and its receptors [J].FASEBJ,1999,13(1):9-22
[4]陶清国,张珍样.肺血管结构改建,平滑肌细胞增生与原癌基因 [J].国外医学呼吸系统分册.1997.17(1):22-24
[5] Baudino TA, McKay C, Pendeville-Samain H,et al. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 2002 Oct 1;16(19):2530-43
[6] Pelengaris S, Khan M, Evan GI.Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell. 2002 May 3;109(3):321-34
[7] 刘智敏,严律南,赵永恒等.胆管癌组织中VEGF和c-myc的表达及其意义[J].中国普外基础与临床杂志.2004.2:139-141
[8] Ulrike E, Knies-Bamforth, Stephen B. Fox, et al. c-Myc Interacts with Hypoxia to Induce Angiogenesis In vivo by a Vascular Endothelial Growth Factor-Dependent MechanismCancer Research 64, 6563-6570, September 15, 2004
[9] LiuY,CoxSR,MoritaT,etal.Hypoxiaregulatesvascularendothelialgrowthfactorgeneexpressioninendothelialcells:i dentificationofa5 enhancer[J].CircRes,1995,77(3):638-643
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