蟾蝓保元汤治疗晚期非小细胞肺癌未放化疗19例临床观察(1)
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【摘要】背景与目的探讨在无放化疗状态下蟾蝓保元汤对晚期非小细胞肺癌(NSCLC)的生存期影响。方法 19例NSCLC用蟾蝓保元汤治疗3~38个月。另从2005~2007年未用放化疗的139例晚期NSCLC患者中选出19例作为配对试验组进行比较。同时研究了蟾蝓保元汤对患者的毒性反应。结果蟾蝓保元汤组的生存期明显长于对照组(生存率：1年0.579 vs 0.105，2年 0.347 vs 0， t=4.8959,P< 0.001).治疗3个月的前后血液学指标无统计学差异，体重保持不变。肝肾功能未受影响，PS好转有显著差异(P< 0.01)结论蟾蝓保元汤能显著延长晚期肺癌患者的生存期,且无人体的毒害作用。
【关键词】蟾蝓保元汤， 晚期非小细胞肺癌，生存期，临床毒性。
Clinical Observation on without radiotherapy and chemotherapy for 19 Patients with Advanced-stage NSCLC by Chanyubaoyuan Decoction
SU Eryun1 ZHANGYongkui2 LE Hanpo2 CHENGZhijun2 ZHANGBinji2 XU Guili2
【Abstract】ObjectiveTo investigate the effect of this treatment for the survival time for the patients with advanced-stage lung cancer. Methods19 NSCLC patients were treated by Chanyubaoyuan Decoction for 3-38 months. The survival time of these patients were compared with 19 paired patients from without chemoradiotherapy for 139 patients with advanced NSCLC during the corresponding period (2005-2007). At the same time, the toxicant responses of Chanyubaoyuan Decoction were researched on the patients. ResultsThe survival time of the patients with Chanyubaoyuan Decoction had longer than the control group significantly (survival rate : 1 yr: 0.579 vs 0.105, 2 yrs: 0.347 vs 0, t = 4.8959,P< 0.001)The hematopoietic toxicity, hepatotoxicity and nephrotoxicity was not observed after 3 months treatment. The body weight of the patients remained the same and PS was improved during the treatment with Chanyubaoyuan Decoction.ConclusionThesurvival time of the patients with advanced-stage lung cancer was increased after the treatment with Chanyubaoyuan Decoction.
KeywordsChanyubaoyuan Decoction；advanced-stage NSCLC；survival time, clinical toxicities
【中图分类号】R263【文献标识码】B【文章编号】1005-0515(2011)02-0001-02
肺癌是导致死亡的首位恶性肿瘤。大多数患者检出时已是不能手术的晚期病人。其自然病史生存期极短，中位数生存期只有1~4个月。通常对晚期肺癌的化疗是以铂为基础的联合化疗。但非小细胞性肺癌(NSCLC)本身对化疗的不敏感性导致疗效难以提高，且化疗的临床毒性限制了化疗应用的完整性。晚期肺癌患者大多是老年患者，在中国，多数的老年患者及其家属对放化疗毒副作用的忧虑远胜过治疗。他们获知肺癌后，往往寻找中医治疗。所以对晚期肺癌, 研究控制其发展，延长生存期，毒性又低的中医药治疗，迫在眉间。我们在长期的临床工作中自创蟾蝓保元汤治疗晚期肺癌获得较好的疗效，现报道如下。
1 材料与方法
1.1 一般资料:19例患者来自2005年6月到2007年12月来舟山医院的初诊病人 ......
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