护心胶囊对心房纤颤伴慢性舒张性心力衰竭(心阳不振型)患者临床疗效及血浆NT-proBNP水平的影响(1)
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【摘要】目的:通过观察护心胶囊对心房纤颤伴慢性舒张性心力衰竭(心阳不振型)患者临床疗效及血浆NT-proBNP水平的影响，评价护心胶囊的临床疗效并探讨其作用机制。方法: 将符合纳入标准的60例患者随机分为对照组、治疗组，每组30例。对照组在常规治疗的基础上给予胺碘酮治疗。治疗组在对照组治疗基础上给予护心胶囊。治疗1个月后观察心房纤颤的转复或心室率控制情况，及血浆氨基末端脑钠肽前体(NT-proBNP)水平。结果:两组用药后心室率均明显下降,部分转复者能维持窦性心律,并且治疗组总有效率显著高于对照组。两组用药前后血清NT-proBNP水平下降明显，具有统计学意义(P<0.01),并且治疗组优于对照组(P<0.05)。结论: 护心胶囊治疗心房纤颤伴慢性舒张性心力衰竭(心阳不振型)患者的疗效确切，其能有效地转复或控制心房纤颤的心室率，改善患者的心功能。
【关键词】护心胶囊;心房纤颤;舒张性心力衰竭; 血浆NT-proBNP
【Abstract】 Objective：to study the clinical efficacy of HuXin capsule on patients in diastolic heart failure with chronic atrial fibrillation (heart yang deficiency) and plasma level of NT-proBNP, evaluate the clinical efficacy of HuXin capsule and discuss the mechanism. Methods: divide randomly the inclusion criterria 60 patients into control group, treatment group,n=30. The control group is given amiodarone on the basis of routine treatment . The treatment group is given HuXin capsule on the basis of the control group. Observe the cardioversion of atrial fibrillation or the ventricular rate control situation after one-month treatment, and plasma level of N-terminal brain natriuretic peptide (NT-proBNP). Results: Both groups of ventricular rate are decreased significantly after the treatment, some cardioversioners are able to maintain sinus rhythm and the efficiency of the treatment group is significantly higher than the control group.Both groups of serum NT-proBNP levels are decreased significantly after treatment, with statistical significance (P <0.01), and the treatment group is better than the control group (P <0.05). Conclusion: HuXin capsule treat,the patients in diastolic heart failure with chronic atrial fibrillation (heart yang deficiency) definitely, it can effectively cardiover or control the ventricular rate of atrial fibrillation ,improving cardiac function
【Key Words】HuXin capsule; atrial fibrillation; diastolic heart failure; plasma level of NT-proBNP
【中图分类号】R415【文献标识码】A【文章编号】1005-0515(2011)04-0032-02
随着社会老龄化的增长, 心房纤颤(A F)与心力衰竭(H F)越来越普遍, 且心房纤颤与心力衰竭是经常伴随一起的两种病症， Framingham研究中，心房纤颤10年随访有1/3人最终发生心力衰竭[1]；我国的资料显示，住院的心房纤颤患者中有三分之一存在心力衰竭[2] ......
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