超敏C反应蛋白等指标检测在慢性阻塞性肺疾病急性加重期的临床价值(1)
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【摘要】目的：观察血清超敏C 反应蛋白(Supersensitivity-C reactive protein，hs-CRP)及其与肺功能等指标的相关性，探讨hs-CRP等指标检测在慢性阻塞性肺病急性加重期患者中的临床意义。方法：对收住院的65 例COPD 急性加重期(AECOPD)患者在入院治疗前和经治疗病情缓解后进行血清hs-CRP含量及肺功能第1秒用力呼气容积(FEV1)占用力肺活量(FVC)百分比(FEV1/FVC)、血气分析、白细胞计数(WBC)等检测并进行比较。结果：AECOPD患者在入院治疗前、治疗病情缓解后及正常对照组hs-CRP水平分别为58.76±6.5、6.12±1.42 和2.64±1.15(mg/l)，COPD 急性加重期患者hs-CRP水平明显高于正常对照组，差异具有统计学意义(P<0.01)，治疗稳定后hs-CRP 浓度与正常对照组相比仍偏高，但差异无统计学意义。且hs-CRP变化与FEV1/FVC、PO2水平负相关；与PCO2 、WBC水平正相关。 结论：hs-CRP 检测可作为COPD 急性加重期的诊断及严重度评估的一个灵敏指标。
【关键词】超敏C 反应蛋白；慢性阻塞性肺病；急性加重期
Clinical Value of Index Detection likeHigh Sensitivity C - reactive Protein in AECOPD
A Xuande
【Abstract】Objective: to observe High Sensitivity C-Reactive Protein (hs-CRP) of serum and relevance with index like lung function; to study clinical value of index detection like hs-CRP of the patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease (AECOPD). Method: to detect the content of hs-CRP of serum, FEV1/FVC of lung function during the first second, blood gas analysis and white cell count, etc. of 65 patients with AECOPE and their comparison before admission and remission after the treatment. Results: the level of hs-CRP of the patients with AECOPD: before admission 58.76±6.5 mg/l, remission after the treatment 6.12±1.42mg/l, normal control group 2.64±1.15 mg/l. The level of hs-CRP of the patients with AECOPD is obviously higher than of the normal control group. There is a statistical significance (P<0.01) with the difference. The concentration of hs-CRP after the treatment is still higher than of the normal control group, but there is no statistical significance. There is negative correlation between the change of hs-CRP and the level of FEV1/FVC, PO2 and positive correlation between the change of hs-CRP and the level of PCO2, WBC. Conclusion: hs-CRP detection can be used as a sensitive index in diagnosis and severity assessment of AECOPD.
【Key words】High Sensitivity C-Reactive Protein, COPD, acute exacerbation.
【中图分类号】R758 【文献标识码】B 【文章编号】1005-0515(2011)06-0013-02 ......
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