稳消方干预颈动脉粥样硬化斑块临床研究
摘要：目的 观察稳消方干预颈动脉粥样硬化(CAS)斑块形成患者颈动脉斑块变化情况,同时评估用药安全性。方法 将60例CAS斑块形成患者随机分为干预组33例及对照组27例,对照组予常规治疗,干预组在常规治疗基础上加用稳消方,并进一步分为干预半年组与对照半年组、干预1年组与对照1年组进行比较,采用颈动脉彩色多普勒超声评估斑块状况,同时测定肝、肾功能指标。结果 与对照组治疗后比较,干预半年组及1年组平均斑块数量、斑块最大厚度、Crouse积分比较差异有统计学意义(P<0.05,P<0.01),而斑块的稳定性干预1年组优于半年组；与本组治疗前比较,对照组斑块数量增多、增大,Crouse积分增加(P<0.05,P<0.01)。干预组及对照组双侧颈总动脉内径、内膜-中层厚度及肝、肾功能治疗前后比较差异均无统计学意义(P>0.05)。结论 稳消方治疗CAS斑块形成疗效确切、安全性良好,且随干预时间延长,稳定斑块趋势更为明显。
关键词：稳消方；颈动脉粥样硬化斑块；中医药疗法
DOI：10.3969/j.issn.1005-5304.2013.08.006
中图分类号：R259.435
文献标识码：A
文章编号：1005-5304(2013)08-0015-04Clinical Research on Wenxiao Decoction in Treatment of Carotid Atherosclerostic Plaque HUANG Kan, HUO Qing-ping, WANG Yu-xin, PENG Wen-bo, LIANG Fang (Department of TCM, The Sixth People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China)
Abstract：Objective To observe the effect of Wenxiao Decoction in treating the patients with carotid atherosclerostic (CAS) plaque and assess the safety. Methods Sixty patients with CAS plaque were randomly allocated to treatment group (33 cases) and control group (27 cases). The control group was given routine therapy, and the treatment group was given Wenxiao Decoction additionally. And they were further divided into half-year treatment group and half-year control group, 1-year treatment group and 1-year control group. Carotid artery color Doppler ultrasound and hepatorenal function were examined before and after treatment. Results Compared with the control groups after therapy, the average numbers of plaques, maximal plaque thickness, Crouse plaque integral were decreased both in 1-year and half-year treatment groups (P<0.05, P<0.01). The plaque stability of 1-year treatment group was better than that of half-year treatment group. The average numbers of plaques, plaques size and Crouse plaque integral increased in control groups after routine therapy (P<0.05, P<0.01). Bilateral common carotid artery diameter, intima-medial thickness (IMT) and hepatorenal function had no statistical difference between before and after treatment both in treatment and control groups (P>0.05). Conclusion Wenxiao Decoction is effective and safe in treatment of CAS plaque, and plaque stability is more obvious with the extension of treatment time.
Key words：Wenxiao Decoction；carotid atherosclerostic plaque；Chinese medicine
动脉粥样硬化(artherosclerosis,AS)是引发心脑血管疾病的共同病理基础。颈动脉作为全身动脉的一部分,是最易受累的大血管之一。颈动脉粥样硬化(carotid atherosclerosis, CAS)即指双侧颈总动脉、颈总动脉分叉处及颈内、外动脉颅外段血管壁僵硬,内膜下脂质沉积、斑块形成及管腔狭窄等[1]。CAS是全身动脉粥样硬化斑块形成在颈部的表现,由于位置表浅,易探查,可作为全身AS情况的“窗口”。稳消方是本院霍清萍主任临床用于治疗CAS斑块的经验方。本研究采用颈动脉高基金项目：上海市卫生局中医药科研基金(2012QL022A)；上海市第六人民医院院级科学研究基金(院-1454)通讯作者：霍清萍,E-mail：huoqingping005@yahoo.com.cn频彩色多普勒超声检测手段,以了解经稳消方干预后CAS患者颈动脉内膜及斑块变化情况,进一步明确其治疗CAS的疗效,同时评估其用药安全性。1 临床资料1.1 一般资料
选取2010年9月-2012年3月符合要求的CAS患者60例,均来自本院中医科门诊及病房。依据随机数字表法随机分为干预组33例和对照组27例。干预组再随机分为干预半年组14例,男9例,女5例,平均年龄(72.86±8.76)岁；干预1年组19例,男7例,女12例,平均年龄(68.84±9.79)岁。对照组同样随机分为对照半年组13例,男8例,女5例,平均年龄(73.54±8.69)岁；对照1年组14例,男6例,女8例,平均年龄(72.64±4.73)岁。干预半年组与对照半年组、干预1年组与对照1年组在年龄、性别、斑块状况方面比较,差异均无统计学意义(P>0.05)。, http://www.100md.com(黄侃,霍清萍 王宇新 彭文波 梁芳)
关键词：稳消方；颈动脉粥样硬化斑块；中医药疗法
DOI：10.3969/j.issn.1005-5304.2013.08.006
中图分类号：R259.435
文献标识码：A
文章编号：1005-5304(2013)08-0015-04Clinical Research on Wenxiao Decoction in Treatment of Carotid Atherosclerostic Plaque HUANG Kan, HUO Qing-ping, WANG Yu-xin, PENG Wen-bo, LIANG Fang (Department of TCM, The Sixth People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China)
Abstract：Objective To observe the effect of Wenxiao Decoction in treating the patients with carotid atherosclerostic (CAS) plaque and assess the safety. Methods Sixty patients with CAS plaque were randomly allocated to treatment group (33 cases) and control group (27 cases). The control group was given routine therapy, and the treatment group was given Wenxiao Decoction additionally. And they were further divided into half-year treatment group and half-year control group, 1-year treatment group and 1-year control group. Carotid artery color Doppler ultrasound and hepatorenal function were examined before and after treatment. Results Compared with the control groups after therapy, the average numbers of plaques, maximal plaque thickness, Crouse plaque integral were decreased both in 1-year and half-year treatment groups (P<0.05, P<0.01). The plaque stability of 1-year treatment group was better than that of half-year treatment group. The average numbers of plaques, plaques size and Crouse plaque integral increased in control groups after routine therapy (P<0.05, P<0.01). Bilateral common carotid artery diameter, intima-medial thickness (IMT) and hepatorenal function had no statistical difference between before and after treatment both in treatment and control groups (P>0.05). Conclusion Wenxiao Decoction is effective and safe in treatment of CAS plaque, and plaque stability is more obvious with the extension of treatment time.
Key words：Wenxiao Decoction；carotid atherosclerostic plaque；Chinese medicine
动脉粥样硬化(artherosclerosis,AS)是引发心脑血管疾病的共同病理基础。颈动脉作为全身动脉的一部分,是最易受累的大血管之一。颈动脉粥样硬化(carotid atherosclerosis, CAS)即指双侧颈总动脉、颈总动脉分叉处及颈内、外动脉颅外段血管壁僵硬,内膜下脂质沉积、斑块形成及管腔狭窄等[1]。CAS是全身动脉粥样硬化斑块形成在颈部的表现,由于位置表浅,易探查,可作为全身AS情况的“窗口”。稳消方是本院霍清萍主任临床用于治疗CAS斑块的经验方。本研究采用颈动脉高基金项目：上海市卫生局中医药科研基金(2012QL022A)；上海市第六人民医院院级科学研究基金(院-1454)通讯作者：霍清萍,E-mail：huoqingping005@yahoo.com.cn频彩色多普勒超声检测手段,以了解经稳消方干预后CAS患者颈动脉内膜及斑块变化情况,进一步明确其治疗CAS的疗效,同时评估其用药安全性。1 临床资料1.1 一般资料
选取2010年9月-2012年3月符合要求的CAS患者60例,均来自本院中医科门诊及病房。依据随机数字表法随机分为干预组33例和对照组27例。干预组再随机分为干预半年组14例,男9例,女5例,平均年龄(72.86±8.76)岁；干预1年组19例,男7例,女12例,平均年龄(68.84±9.79)岁。对照组同样随机分为对照半年组13例,男8例,女5例,平均年龄(73.54±8.69)岁；对照1年组14例,男6例,女8例,平均年龄(72.64±4.73)岁。干预半年组与对照半年组、干预1年组与对照1年组在年龄、性别、斑块状况方面比较,差异均无统计学意义(P>0.05)。, http://www.100md.com(黄侃,霍清萍 王宇新 彭文波 梁芳)