敦煌遗书《辅行诀》用药规律数据挖掘研究(1)
摘要：目的 运用数据挖掘技术分析敦煌遗书《辅行诀》用药规律，以期为临床利用敦煌方药辨治内科疾病提供依据。方法 计算机录入敦煌遗书《辅行诀》治疗内科疾病的中医方剂，采用Excel 2003软件建立相应数据库，运用数据挖掘方法分析其用药规律。结果 整理出敦煌遗书《辅行诀》中医方剂61首，涉及药物66味，药物总使用频次336次。所用核心单味药依次为甘草、白芍、干姜、生姜、黄芩、旋覆花、人参、大枣、竹叶、五味子、桂枝等；药物类别以补虚药、清热药、解表药、温里药、化痰止咳平喘药为主，累计频率为80.66%；药味以苦、甘、辛为主，累计频率达83.91%；药性以寒、温、平为主，累计频率达87.95%；归经以胃、肺、脾、心、肾、肝经为主，累计频率达86.15%。敦煌医术类方剂治疗内科疾病临床用药配伍以补气药甘草、人参、大枣，补血药白芍，滋阴药麦门冬为主，次以清热药竹叶、黄芩为辅，再以解表药生姜、桂枝，温里药干姜，化痰止咳平喘药旋覆花，收涩药五味子等为特色用药。高频次药物构成敦煌医术类方剂中治疗天行病的小阴旦汤。结论 本研究总结出了敦煌《辅行诀》临床用药配伍规律体系，可为临床用药及研发新药提供参考。
关键词：敦煌遗书；辅行诀；数据挖掘；用药规律
中图分类号：R24；R2-05 文献标识码：A 文章编号：1005-5304(2016)05-0037-03
Study on Medication Rules of Dunhuang Manuscripts Fu Xing Jue Based on Data Mining LI Ting-bao (Gansu University of Chinese Medicine， Lanzhou 730000， China)
Abstract： Objective To provide references for the clinical application of Dunhuang prescriptions for treating internal medicine diseases by analyzing medication rules of Dunhuang manuscripts Fu Xing Jue based on data mining method. Methods TCM prescriptions for internal medicine diseases in the Dunhuang manuscripts Fu Xing Jue were input computer. Excel 2003 software was used to establish relevant database. Data mining method was used to analyze the medication rules. Results There were 61 TCM prescriptions in the Dunhuang manuscripts Fu Xing Jue， including 66 kinds of Chinese herbal medicine and 336 times of total frequency of usage. The used core single herbs were as follows： Glycyrrhizae Radix et Rhizoma， Paeoniae Radix Alba， Zingiberis Rhizoma， Zingiberis Rhizoma Recens， Scuteliariae Radix， Inulae Flos， Ginseng Radix et Rhizoma， Jujubae Fructus， Lophatheri Herba， Schisandrae Chinensis Fructus， and Cinnamomi Ramulus； medicine types were tonifying-deficiency medicine， heat-clearing medicine， relieving exterior syndrome medicine， interior-warming medicine and antitussive and antiasthmatic medicine， with the cumulative frequency of 80.66%； medicine flavors were bitterness， sweetness and pungentness， with the cumulative frequency of 83.91%； medicine properties were coldness， warmness and peace， with the cumulative frequency of 87.95%； channel tropisms were stomach， lung， spleen， heart， kidney and liver， with the cumulative frequency of 86.15%. Clinical compatibility of medicines for treating internal medicine diseases in Dunhuang medical prescriptions were mainly qi-tonifying medicines (Glycyrrhizae Radix et Rhizoma， Ginseng Radix et Rhizoma and Jujubae Fructus)， blood-replenishing medicine (Paeoniae Radix Alba)， and nourishing medicines (Ophiopogonis Radix)， supplemented by heat-clearing medicine (Lophatheri Herba and Scuteliariae Radix)，with relieving exterior syndrome medicines (Zingiberis Rhizoma Recens and Cinnamomi Ramulus)， interior-warming medicine (Zingiberis Rhizoma)， antitussive and antiasthmatic medicine (Inulae Flos)， inducing astringency medicine, 百拇医药(李廷保)
关键词：敦煌遗书；辅行诀；数据挖掘；用药规律
中图分类号：R24；R2-05 文献标识码：A 文章编号：1005-5304(2016)05-0037-03
Study on Medication Rules of Dunhuang Manuscripts Fu Xing Jue Based on Data Mining LI Ting-bao (Gansu University of Chinese Medicine， Lanzhou 730000， China)
Abstract： Objective To provide references for the clinical application of Dunhuang prescriptions for treating internal medicine diseases by analyzing medication rules of Dunhuang manuscripts Fu Xing Jue based on data mining method. Methods TCM prescriptions for internal medicine diseases in the Dunhuang manuscripts Fu Xing Jue were input computer. Excel 2003 software was used to establish relevant database. Data mining method was used to analyze the medication rules. Results There were 61 TCM prescriptions in the Dunhuang manuscripts Fu Xing Jue， including 66 kinds of Chinese herbal medicine and 336 times of total frequency of usage. The used core single herbs were as follows： Glycyrrhizae Radix et Rhizoma， Paeoniae Radix Alba， Zingiberis Rhizoma， Zingiberis Rhizoma Recens， Scuteliariae Radix， Inulae Flos， Ginseng Radix et Rhizoma， Jujubae Fructus， Lophatheri Herba， Schisandrae Chinensis Fructus， and Cinnamomi Ramulus； medicine types were tonifying-deficiency medicine， heat-clearing medicine， relieving exterior syndrome medicine， interior-warming medicine and antitussive and antiasthmatic medicine， with the cumulative frequency of 80.66%； medicine flavors were bitterness， sweetness and pungentness， with the cumulative frequency of 83.91%； medicine properties were coldness， warmness and peace， with the cumulative frequency of 87.95%； channel tropisms were stomach， lung， spleen， heart， kidney and liver， with the cumulative frequency of 86.15%. Clinical compatibility of medicines for treating internal medicine diseases in Dunhuang medical prescriptions were mainly qi-tonifying medicines (Glycyrrhizae Radix et Rhizoma， Ginseng Radix et Rhizoma and Jujubae Fructus)， blood-replenishing medicine (Paeoniae Radix Alba)， and nourishing medicines (Ophiopogonis Radix)， supplemented by heat-clearing medicine (Lophatheri Herba and Scuteliariae Radix)，with relieving exterior syndrome medicines (Zingiberis Rhizoma Recens and Cinnamomi Ramulus)， interior-warming medicine (Zingiberis Rhizoma)， antitussive and antiasthmatic medicine (Inulae Flos)， inducing astringency medicine, 百拇医药(李廷保)