解毒清肺合剂对慢性阻塞性肺疾病模型大鼠肺组织中性粒细胞弹性蛋白酶及黏蛋白5AC表达的影响(2)
MUC5AC mRNA expression in lung tissue compared with clarithromycin group. MUC5AC protein expression on airway epithelium in Jiedu Qingfei group significantly decreased (P<0.05)， as same as clarithromycin group. Jiedu Qingfei group and clarithromycin group had no difference on NE protein expression in airway epithelium compared with model group. Conclusion Jiedu Qingfei group Mixture can reduce airway mucus hypersecretion of COPD by down-regulating MUC5AC expression through neutrophil elastase.Key words： Jiedu Qingfei Mixture； chronic obstructive pulmonary disease； airway mucus hypersecretion； neutrophil elastase； MUC5AC； rats
慢性阻塞性肺疾病(chronic obstructive pulmonary disease ......
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