润肠宣肺疏肝方治疗慢传输型便秘临床观察(1)
摘要：目的 观察润肠宣肺疏肝方治疗慢传输型便秘(STC)的临床疗效。方法 将94例患者随机分为治疗组和对照组各47例。治疗组予润肠宣肺疏肝方，每日1剂，早晚分服。对照组予乳果糖口服液，每次15 mL，早晚口服；枸橼酸莫沙必利片5 mg，每日3次，餐前口服。2组均治疗4周，随访3个月。观察排便症状积分、Zung氏焦虑自评量表(SAS)及抑郁自评量表(SDS)评分，并行结肠传输试验，记录不良反应情况。结果 与本组治疗前比较，2组治疗后排便困难程度、排便次数、排便时间、腹胀、粪便性状评分明显降低(P<0.05)，治疗后及治疗后3个月治疗组较对照组明显下降(P<0.05)。与治疗前比较，治疗组治疗后及治疗后3个月SAS、SDS评分明显下降(P<0.05)，与对照组同一时点比较差异有统计学意义(P<0.05)。与治疗前比较，2组治疗后结肠传输功能明显改善(P<0.05)，2组比较差异无统计学意义(P>0.05)。结论 润肠宣肺疏肝方可改善STC临床症状，缓解患者焦虑抑郁情绪，促进结腸传输功能。
关键词：慢传输型便秘；润肠宣肺疏肝方；临床疗效
DOI：10.3969/j.issn.1005-5304.2017.05.007
中图分类号：R259.746.2 文献标识码：A 文章编号：1005-5304(2017)05-0027-04
Clinical Observation of Runchang Xuanfei Shugan Formula in Treatment of Slow Transit Constipation LIU Tao1， ZHANG Xia2， WEI Wei1 (1. Wangjing Hospital， China Academy of Chinese Medical Sciences， Beijing 100102， China； 2. Datong University School of Medicine， Datong 037000， China)
Abstract： Objective To observe the clinical efficacy of Runchang Xuanfei Shugan Formula in the treatment of slow transit constipation. Methods Totally 94 patients were randomly divided into treatment group and control group， with 47 patients in each group. Treatment group was given Runchang Xuanfei Shugan Formula， one dose per day， half a dose for morning and half a dose for evening， and the control group was given lactulose oral liquid， 15 mL each time， for morning and evening， and citrate moser Billy 5 mg， three times a day orally taken before meals. The treatment course for the two groups were 4 weeks， with three-month follow-up. The defecation symptom score， anxiety and depression score were observed， the colonic transit test meter was performed， and the side effects were recorded. Results The degree of defecation difficulty， defecation frequency， defecation time， abdominal distension and stool quality score of the two groups significantly decreased after treatment (P<0.05)， and the treatment group was much lower than the control group after treatment and three months after treatment (P<0.05). The score of anxiety and depression (SAS， SDS) of the treatment group decreased significantly after treatment and three months after treatment (P<0.05)， and had significant differences with the control group (P<0.05). The colon function was significantly improved after treatment in both groups (P<0.05)， without statistical significance (P>0.05). Conclusion Runchang Xuanfei Shugan Formula can improve clinical symptoms of slow transit constipation， ease anxiety and depression of patients， and promote colon transmission function., 百拇医药(刘涛 张霞 魏玮)
关键词：慢传输型便秘；润肠宣肺疏肝方；临床疗效
DOI：10.3969/j.issn.1005-5304.2017.05.007
中图分类号：R259.746.2 文献标识码：A 文章编号：1005-5304(2017)05-0027-04
Clinical Observation of Runchang Xuanfei Shugan Formula in Treatment of Slow Transit Constipation LIU Tao1， ZHANG Xia2， WEI Wei1 (1. Wangjing Hospital， China Academy of Chinese Medical Sciences， Beijing 100102， China； 2. Datong University School of Medicine， Datong 037000， China)
Abstract： Objective To observe the clinical efficacy of Runchang Xuanfei Shugan Formula in the treatment of slow transit constipation. Methods Totally 94 patients were randomly divided into treatment group and control group， with 47 patients in each group. Treatment group was given Runchang Xuanfei Shugan Formula， one dose per day， half a dose for morning and half a dose for evening， and the control group was given lactulose oral liquid， 15 mL each time， for morning and evening， and citrate moser Billy 5 mg， three times a day orally taken before meals. The treatment course for the two groups were 4 weeks， with three-month follow-up. The defecation symptom score， anxiety and depression score were observed， the colonic transit test meter was performed， and the side effects were recorded. Results The degree of defecation difficulty， defecation frequency， defecation time， abdominal distension and stool quality score of the two groups significantly decreased after treatment (P<0.05)， and the treatment group was much lower than the control group after treatment and three months after treatment (P<0.05). The score of anxiety and depression (SAS， SDS) of the treatment group decreased significantly after treatment and three months after treatment (P<0.05)， and had significant differences with the control group (P<0.05). The colon function was significantly improved after treatment in both groups (P<0.05)， without statistical significance (P>0.05). Conclusion Runchang Xuanfei Shugan Formula can improve clinical symptoms of slow transit constipation， ease anxiety and depression of patients， and promote colon transmission function., 百拇医药(刘涛 张霞 魏玮)