三黄汤联合利拉鲁肽注射液治疗老年2型糖尿病合并肥胖临床研究(1)
摘要：目的 研究三黄汤联合利拉鲁肽注射液治疗老年2型糖尿病(T2DM)合并肥胖的临床疗效，并探讨其可能的作用机制。方法 采用随机数字表法将老年T2DM合并肥胖患者分为对照组和研究组各66例。对照组予利拉鲁肽注射液，每日1次，最大剂量<1.8 mg/d(每2周进行调整)，皮下注射；研究组在对照组基础上予三黄汤，每日1剂，早晚冲服。2组均3个月为1个疗程。分析2组临床疗效，观察2组治疗前后糖脂代谢指标(空腹血糖、糖化血红蛋白、胰岛素抵抗指数、总胆固醇、三酰甘油、载脂蛋白B)、氧化应激指标和炎症因子水平，比较不良反应。结果 研究组总有效率为90.91%(60/66)，对照组为69.70%(46/66)，2组比较差异有统计学意义(P<0.05)。与本组治疗前比较，2组治疗后糖脂代谢指标，血清丙二醛、过氧化氢酶及血浆肿瘤坏死因子-α、白细胞介素-6、超敏C反应蛋白水平明显下降，血清谷胱甘肽过氧化物酶、超氧化物歧化酶及血浆脂联素水平显著升高(P<0.05)；2组治疗后比较，研究组糖脂代谢指标、氧化应激指标和炎症因子水平改善明显优于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论 三黄汤联合利拉鲁肽注射液治疗老年T2DM合并肥胖疗效显著，其机制与影响糖脂代谢、氧化应激反应和炎症反应相关。
关键词：三黄汤；利拉鲁肽注射液；2型糖尿病，老年；肥胖
中图分类号：R259.871 文献标识码：A 文章编号：1005-5304(2019)03-0029-05
Abstract： Objective To study the clinical efficacy of Sanhuang Decoction combined with liraglutide injection for the treatment of senile type 2 diabetes mellitus (T2DM) with obesity； To explore the possible mechanism of action. Methods According to the random number table method， 132 cases of elderly patients with T2DM complicated with obesity were divided into control group and study group， with 66 cases in each group. Patients in the control group were treated with liraglutide injection， once a day， the maximum injection <1.8 mg/d (changed every two weeks)， subcutaneous injection； while patients in the study group were treated with Sanhuang Decoction on the basis of the control group， one dosage per day， taken in the morning and evening. Three months were one treatment course for each group. The clinical efficacy of the two groups was analyzed. The glucolipid metabolism indexes (fasting blood glucose， glycosylated hemoglobin， insulin resistance index， total cholesterol， triglyceride， apolipoprotein B)， oxidative stress and inflammatory factors were observed before and after treatment. Adverse reactions of both groups were compared. Results The total effective rate was 90.91% (60/66) in the study group and 69.70% (46/66) in the control group， with statistical significance (P<0.05). Compared with before treatment， the levels of glucolipid metabolismindex， serum MDA， CAT， and plasma TNF-α， IL-6 and hs-CRP in both groups significantly decreased， while the levels of serum GSH?Px， SOD and plasma ADP significantly increased (P<0.05). After treatment， glucolipid metabolism， oxidative stress and inflammation factors of the study group were better than control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Sanhuang Decoction combined with liraglutide injection can treat elderly patients with T2DM complicated with obesity through affectting glycolipid metabolism， oxidative stress and inflammatory response., http://www.100md.com(艾力亚斯·阿不拉 赖敬波)
关键词：三黄汤；利拉鲁肽注射液；2型糖尿病，老年；肥胖
中图分类号：R259.871 文献标识码：A 文章编号：1005-5304(2019)03-0029-05
Abstract： Objective To study the clinical efficacy of Sanhuang Decoction combined with liraglutide injection for the treatment of senile type 2 diabetes mellitus (T2DM) with obesity； To explore the possible mechanism of action. Methods According to the random number table method， 132 cases of elderly patients with T2DM complicated with obesity were divided into control group and study group， with 66 cases in each group. Patients in the control group were treated with liraglutide injection， once a day， the maximum injection <1.8 mg/d (changed every two weeks)， subcutaneous injection； while patients in the study group were treated with Sanhuang Decoction on the basis of the control group， one dosage per day， taken in the morning and evening. Three months were one treatment course for each group. The clinical efficacy of the two groups was analyzed. The glucolipid metabolism indexes (fasting blood glucose， glycosylated hemoglobin， insulin resistance index， total cholesterol， triglyceride， apolipoprotein B)， oxidative stress and inflammatory factors were observed before and after treatment. Adverse reactions of both groups were compared. Results The total effective rate was 90.91% (60/66) in the study group and 69.70% (46/66) in the control group， with statistical significance (P<0.05). Compared with before treatment， the levels of glucolipid metabolismindex， serum MDA， CAT， and plasma TNF-α， IL-6 and hs-CRP in both groups significantly decreased， while the levels of serum GSH?Px， SOD and plasma ADP significantly increased (P<0.05). After treatment， glucolipid metabolism， oxidative stress and inflammation factors of the study group were better than control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Sanhuang Decoction combined with liraglutide injection can treat elderly patients with T2DM complicated with obesity through affectting glycolipid metabolism， oxidative stress and inflammatory response., http://www.100md.com(艾力亚斯·阿不拉 赖敬波)