基于数据挖掘的中药治疗面肌痉挛用药规律研究(1)
摘要：目的 分析中药治疗面肌痉挛的用药规律，为临床治疗提供参考。方法 计算机检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)建库至2018年6月30日发表的中药治疗面肌痉挛相关文献。采用古今医案云平台(V1.4.14)对纳入处方药物频次、性味归经、常用药对、核心药物组合等进行分析。结果 纳入处方101首，涉及药物131种，药性以平性及甘、辛、苦味为主，主要归肝、脾、肺经。处方中常用药对有僵蚕-全蝎等，复杂网络分析得出核心药物组合为白芍、僵蚕、白附子、钩藤、蜈蚣、川芎、甘草、当归、全蝎，可认为是芍药甘草汤合牵正散化裁而来。结论 中药治疗面肌痉挛注重祛风化痰、通络止痉、养血柔肝熄风，尤其重视虫类药的应用;同时，药性分析表明该病具阳气不足的病机，多从肝、风邪角度论治。
关键词：面肌痉挛;中药;数据挖掘;用药规律
中图分类号：R277.765;R2-05 文献标识码：A 文章编号：1005-5304(2019)05-0114-04
DOI：10.3969/j.issn.1005-5304.2019.05.024 开放科学(资源服务)标识码(OSID)：
Abstract： Objective To analyze the medication rules of TCM treatment for hemifacial spasm; To provide references for clinical treatment. Methods Literature about TCM treatment for hemifacial spasm in CNKI， VIP and Wanfang database from establishment to 30th June， 2018 were retrieved. Ancient and modern medical case cloud platform (V1.4.14) was used to analyze medicine frequency， tastes and belonged meridians， common medicine combinations and key prescriptions. Results Totally 101 prescriptions were included， involving 131 kinds of Chinese materia medica. The main property of medicine was even， and tastes were sweet， pungent and bitter. The main belonged meridians were liver meridian， spleen meridian and lung meridian. The medicine combinations with high frequency were Bombyx Batryticatus - Scorpio. The key prescriptions analyzed by complex network were Paeoniae Radix Alba， Bombyx Batryticatus， Typhonii Rhizoma， Uncariae Ramulus cum Uncis， Scolopendra， Chuanxiong Rhizoma， Glycyrrhizae Radix et Rhizoma， Angelicae Sinensis Radix and Scorpio， which were obtained from modified Shaoyao Gancao Decoction and Qianzheng Powder. Conclusion TCM treatment for hemifacial spasm mainly depends on wind and phlegm- removing， smoothing the meridians and stopping convulsion， and nourishing blood and liver to calm liver-wind， especially the use of insect medicine. Property analysis shows that yang-qi deficiency is one of pathogenesis. The treatment mainly depends on liver and pathogenic wind.
Keywords： hemifacial spasm; TCM; data mining; medication rules
面肌痙挛(hemifacial spasm，HFS)是指在排除其他神经系统病变后，一侧或双侧面部肌肉(包括眼轮匝肌、表情肌、口轮匝肌)反复发作的阵发性、不自主抽搐，常由劳累、情绪激动、过于紧张、焦虑等诱发。发病人群主要为中老年人，女性居多，严重时可出现睁眼困难、口角?斜及耳内抽动样杂音。其病情缠绵，难以治愈，不仅影响个人形象和生活治疗，也带来了严重的焦虑、抑郁等心理问题[1]。
现代医学治疗HFS方法包括药物治疗、肉毒素注射及外科手术。其中药物治疗可减轻部分患者症状，但需长期服用，易导致肝肾损害及过敏反应。肉毒素注射则疗效欠稳定，易产生耐受，不适宜作为长期治疗的手段。微血管减压术是目前外科有可能治愈HFS的方法之一，但目前仍存在术后无效、易复发及产生面瘫、听力障碍等术后并发症难题[2]。中医在治疗HFS方面积累了丰富的临床经验。本研究运用古今医案云平台(V1.4.14)对治疗HFS用药规律进行数据挖掘，为临床治疗本病提供参考。, 百拇医药(丘宇慧 黄遂和 郭歆 华荣)
关键词：面肌痉挛;中药;数据挖掘;用药规律
中图分类号：R277.765;R2-05 文献标识码：A 文章编号：1005-5304(2019)05-0114-04
DOI：10.3969/j.issn.1005-5304.2019.05.024 开放科学(资源服务)标识码(OSID)：
Abstract： Objective To analyze the medication rules of TCM treatment for hemifacial spasm; To provide references for clinical treatment. Methods Literature about TCM treatment for hemifacial spasm in CNKI， VIP and Wanfang database from establishment to 30th June， 2018 were retrieved. Ancient and modern medical case cloud platform (V1.4.14) was used to analyze medicine frequency， tastes and belonged meridians， common medicine combinations and key prescriptions. Results Totally 101 prescriptions were included， involving 131 kinds of Chinese materia medica. The main property of medicine was even， and tastes were sweet， pungent and bitter. The main belonged meridians were liver meridian， spleen meridian and lung meridian. The medicine combinations with high frequency were Bombyx Batryticatus - Scorpio. The key prescriptions analyzed by complex network were Paeoniae Radix Alba， Bombyx Batryticatus， Typhonii Rhizoma， Uncariae Ramulus cum Uncis， Scolopendra， Chuanxiong Rhizoma， Glycyrrhizae Radix et Rhizoma， Angelicae Sinensis Radix and Scorpio， which were obtained from modified Shaoyao Gancao Decoction and Qianzheng Powder. Conclusion TCM treatment for hemifacial spasm mainly depends on wind and phlegm- removing， smoothing the meridians and stopping convulsion， and nourishing blood and liver to calm liver-wind， especially the use of insect medicine. Property analysis shows that yang-qi deficiency is one of pathogenesis. The treatment mainly depends on liver and pathogenic wind.
Keywords： hemifacial spasm; TCM; data mining; medication rules
面肌痙挛(hemifacial spasm，HFS)是指在排除其他神经系统病变后，一侧或双侧面部肌肉(包括眼轮匝肌、表情肌、口轮匝肌)反复发作的阵发性、不自主抽搐，常由劳累、情绪激动、过于紧张、焦虑等诱发。发病人群主要为中老年人，女性居多，严重时可出现睁眼困难、口角?斜及耳内抽动样杂音。其病情缠绵，难以治愈，不仅影响个人形象和生活治疗，也带来了严重的焦虑、抑郁等心理问题[1]。
现代医学治疗HFS方法包括药物治疗、肉毒素注射及外科手术。其中药物治疗可减轻部分患者症状，但需长期服用，易导致肝肾损害及过敏反应。肉毒素注射则疗效欠稳定，易产生耐受，不适宜作为长期治疗的手段。微血管减压术是目前外科有可能治愈HFS的方法之一，但目前仍存在术后无效、易复发及产生面瘫、听力障碍等术后并发症难题[2]。中医在治疗HFS方面积累了丰富的临床经验。本研究运用古今医案云平台(V1.4.14)对治疗HFS用药规律进行数据挖掘，为临床治疗本病提供参考。, 百拇医药(丘宇慧 黄遂和 郭歆 华荣)