余承惠运用益肾清利活血法治疗慢性肾脏病用药规律研究(1)
摘要：目的 分析余承惠主任运用益肾清利活血法治疗慢性肾脏病(CKD)用药规律，为临床提供参考。方法 收集2010年9月-2016年4月余承惠于江苏省中医院门诊治疗的CKD患者医案。构建基于Spark的四节点分布式数据挖掘平台，采用频数统计、关联规则、复杂网络等数据挖掘方法，分析处方常用药物、药物性味、归经、功效及藥物之间的关联规则。结果 纳入处方2534首，涉及药物246味，高频药物有白花蛇舌草、白术、茯苓、苍术、川芎、丹参、牡丹皮、黄芪、积雪草、半枝莲、北沙参、墨旱莲、地锦草等;药物性味以甘温、苦寒为主;归经以肝经、脾经及胃经为主。核心处方为黄芪、白术、苍术、茯苓、北沙参、半枝莲、白花蛇舌草、积雪草、川芎、丹参、牡丹皮。结论 余承惠采用益肾清利活血法治疗CKD，其中益肾以益气养阴为主，清利以清热利湿为主，活血以活血行气、活血清热为主。
关键词：益肾清利活血法;慢性肾脏病;余承惠;数据挖掘;名医经验;用药规律
中图分类号：R2-05;R256.5 文献标识码：A 文章编号：1005-5304(2019)06-0106-05
Abstract： Objective To analyze Director YU Chenghui’s medication rules of using Yishen Qingli Huoxue Therapy for treatment of chronic kidney disease (CKD); To provide references for clinic. Methods Clinical cases of CKD treated by YU Chenghui in outpatient of Jiangsu Province Hospital of Chinese Medicine from Sep. 2010 to Apr. 2016 were collected. A four-node distributed data mining platform was built based on Spark. Data mining methods such as frequency statistics， association rules， and complex networks were used to analyze commonly used medicine， medicine taste， meridians， efficacy and the association rules. Results Totally 2534 prescriptions were enrolled， including 246 kinds of Chinese materia medica. High-frequency medicines included Hedyotis diffusa， Atractylodis Macrocephalae Rhizome， Poria， Atractylodis Rhizoma， Chuanxiong Rhizoma， Salviae Miltiorrhizae Radix et Rhizoma， Moutan Cortex， Astragali Radix， Centellae Herba， Scutellariae Barbatae Herba， Glehniae Radix， Ecliptae Herba， and Euphorbiae Humifusae Herba. The medicine properties were mainly warm and cold and the main medicine tastes were sweet and bitter. Medicine efficacy in meridians were mainly in liver， spleen and stomach meridian. The core prescriptions included Astragali Radix， Atractylodis Macrocephalae Rhizome， Atractylodis Rhizoma， Poria， Glehniae Radix， Scutellariae Barbatae Herba， Hedyotis diffusa， Centellae Herba， Chuanxiong Rhizoma， Salviae Miltiorrhizae Radix et Rhizoma， and Moutan Cortex. Conclusion YU Chenghui adopts Yishen Qingli Huoxue Therapy for CKD， in which tonifying spleen is mainly for benefiting qi and nourishing yin， clearing is mainly for clearing heat and dampness， and promoting blood circulation is mainly for promoting blood circulation to regulate qi and promoting blood circulation to clearing heat.
余承惠主任是江苏省名中西医结合专家、“百年金陵名医”、江苏省第二批名老中医药专家传承工作指导老师，从事中西医结合肾病临床研究五十余载，在慢性肾脏病(CKD)治疗上主张辨证与辨病相结合，辅助不足，抑制过亢，以达到平抑病理、维持机体平衡、祛除病邪、恢复机体正常功能的目的[1]。, 百拇医药(高坤 夏平 谢佳东 李蔚)
关键词：益肾清利活血法;慢性肾脏病;余承惠;数据挖掘;名医经验;用药规律
中图分类号：R2-05;R256.5 文献标识码：A 文章编号：1005-5304(2019)06-0106-05
Abstract： Objective To analyze Director YU Chenghui’s medication rules of using Yishen Qingli Huoxue Therapy for treatment of chronic kidney disease (CKD); To provide references for clinic. Methods Clinical cases of CKD treated by YU Chenghui in outpatient of Jiangsu Province Hospital of Chinese Medicine from Sep. 2010 to Apr. 2016 were collected. A four-node distributed data mining platform was built based on Spark. Data mining methods such as frequency statistics， association rules， and complex networks were used to analyze commonly used medicine， medicine taste， meridians， efficacy and the association rules. Results Totally 2534 prescriptions were enrolled， including 246 kinds of Chinese materia medica. High-frequency medicines included Hedyotis diffusa， Atractylodis Macrocephalae Rhizome， Poria， Atractylodis Rhizoma， Chuanxiong Rhizoma， Salviae Miltiorrhizae Radix et Rhizoma， Moutan Cortex， Astragali Radix， Centellae Herba， Scutellariae Barbatae Herba， Glehniae Radix， Ecliptae Herba， and Euphorbiae Humifusae Herba. The medicine properties were mainly warm and cold and the main medicine tastes were sweet and bitter. Medicine efficacy in meridians were mainly in liver， spleen and stomach meridian. The core prescriptions included Astragali Radix， Atractylodis Macrocephalae Rhizome， Atractylodis Rhizoma， Poria， Glehniae Radix， Scutellariae Barbatae Herba， Hedyotis diffusa， Centellae Herba， Chuanxiong Rhizoma， Salviae Miltiorrhizae Radix et Rhizoma， and Moutan Cortex. Conclusion YU Chenghui adopts Yishen Qingli Huoxue Therapy for CKD， in which tonifying spleen is mainly for benefiting qi and nourishing yin， clearing is mainly for clearing heat and dampness， and promoting blood circulation is mainly for promoting blood circulation to regulate qi and promoting blood circulation to clearing heat.
余承惠主任是江苏省名中西医结合专家、“百年金陵名医”、江苏省第二批名老中医药专家传承工作指导老师，从事中西医结合肾病临床研究五十余载，在慢性肾脏病(CKD)治疗上主张辨证与辨病相结合，辅助不足，抑制过亢，以达到平抑病理、维持机体平衡、祛除病邪、恢复机体正常功能的目的[1]。, 百拇医药(高坤 夏平 谢佳东 李蔚)