比浊法测定硫酸抗敌素效价(1)
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摘 要 目的：建立比浊法测定硫酸抗敌素效价的方法。 方法：确定比浊法测定硫酸抗敌素的线性范围，在线性范围内选择高、低剂量对硫酸抗敌素进行效价测定，并与管碟法效价测定结果进行比较。结果与结论：比浊法与管碟法测定结果无明显差异，比浊法测定硫酸抗敌素效价具有精确、便捷等特点，可用于产品质量控制。
关键词 效价 比浊法 管碟法 硫酸抗敌素
中图分类号：R917 文献标识码：B 文章编号：1006-1533(2008)11-0519-03
Turbidimetric method in the determination of titer of colistin sulfate
Bian Jinni, Cao Qiong, Li Ping
(Shanghai Xinxianfeng Pharmaceutical Co, Shanghai,201203)
ABSTRACT Objective:
To establish turbidimetric method to determine the titer of colistin sulfate. Methods: The linear range of colistin sulfate by turbidimetric method was measured and the titer of colistin sulfate at high and low dose in the linear range was tested andthe testing results were compared with those of diffusion method. Results and Conclusion: There was no significant difference between turbidimetric and diffusion method. Turbidimetric method can be used for quality control for its accuracy and convenience.
KEY WORDS turbidimetric method; diffusion method; colistin sulfate
国际上一般采用比浊法和管碟法并行的方法来进行微生物效价测定 ......
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