摘 要 秀丽隐杆线虫在药物和靶蛋白筛选方面越来越受到药物学家的重视，已形成了较为完善的药物筛选技术平台。本文以新药的发现为目标，介绍线虫作为新药筛选模型的特点、研究现状及该模型在新药发现中的应用。

    关键词秀丽隐杆线虫 模型 药物筛选 药靶筛选

    Applications of Caenorhabditis elegans in drug screening

    ZHOU Yu-meng，CHEN Dai-jie*

    (Shanghai Institute of Pharmaceutical Industry of China State Institute of Pharmaceutical Industry，State Key Lab for New Drug and Pharmaceutical Process，Shanghai，200040)

    ABSTRACTCaenorhabditis elegans (C. elegans) has attracted an increasing attention of pharmaceutical scientists working on drug screening. A relatively complete technology platform for drug screening has been formed by this model. The characteristics of C. elegans as new drug screening model ......