当前位置: 首页 > 期刊 > 《上海医药》 > 2013年第1期 > 正文
编号:12335164
Pim—1激酶小分子抑制剂的研究进展(5)
http://www.100md.com 2013年1月1日 孙占莉 肖旭华 袁博
第1页
第3页

    参见附件。

     [16] Schulz MN, Fanghanel J, Schafer M, et al. A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors[J]. Acta Crystallogr D Biol Crystallogr, 2011, 67(Pt3): 156-166.

    [17] Xia Z, Knaak C, Ma J, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases[J]. J Med Chem, 2009, 52(1): 74-86.

    [18] Tong Y, Stewart KD, Thomas S, et al. Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling[J]. Bioorg Med Chem Lett, 2008, 18(19): 5206-5208.

    [19] Cheney IW, Yan S, Appleby T, et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase[J]. Bioorg Med Chem Lett, 2007, 17(6): 1679-1683.

    [20] Debreczeni J?, Bullock AN, Atilla GE, et al. Ruthenium half-sandwich complexes bound to protein kinase Pim-1[J]. Angew Chem Int Ed Engl, 2006, 45(10): 1580-1585.

    [21] Pierce AC, Jacobs M, Stuver-Moody C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase[J]. J Med Chem, 2008, 51(6): 1972-1975.

    [22] Pogacic V, Bullock AN, Fedorov O, et al. Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity[J]. Cancer Research ......

您现在查看是摘要介绍页,详见PDF附件(5209kb)