地氯雷他定口崩片处方及工艺研究
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摘 要 目的：筛选地氯雷他定口崩片的最佳处方和工艺流程，并进行质量研究。方法： 考察不同种类、不同剂量的填充剂和矫味剂对地氯雷他定口崩片口感及崩解时限的影响，并制定合理的质量标准。结果：按照筛选出的最佳处方制备的地氯雷他定口崩片口感易于患者接受，平均崩解时限在30 s之内，且适合工业生产。结论：本法处方合理、工艺简单，生产的片剂可用于临床。
关键词 地氯雷他定 口崩片 崩解时限
中图分类号：R944.4 文献标识码：A 文章编号：1006-1533(2014)07-0058-03
Formulation for the orally disintegrating
tablets of desloratadine and its process research
JIANG Xinyan，SHANG Ding
(Minhang Co.， Ltd of Shanghai New Asiatic Pharmaceuticals， Shanghai 200245， China)
ABSTRACT Objective： To optimize the formulation and process for the orally disintegrating tablets of desloratadine and assess its quality. Methods： The effects of the different types and doses of fillers and flavoring agents on the taste and disintegration of the tablets were studied and a reasonable quality standard was developed. Results： The tablets prepared by optimum formulation were well-tasted ......
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