摘 要 骨肉瘤在新辅助化疗后的原发灶肿瘤组织坏死率对于患者的预后具有决定性意义，寻找有效的检测手段或检测指标在手术前预测化疗疗效，并在术前及时调整治疗显得尤为重要。本文综述基因芯片对骨肉瘤新辅助化疗疗效的预测作用。

    关键词骨肉瘤新辅助化疗坏死率预测基因芯片

    中图分类号：R738.1文献标识码：A文章编号：1006-1533(2014)12-0013-03

    Progress in predicting response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles

    LI Hongtao, SHEN Zan

    (Department of Oncology of Shanghai Six Peoples’ Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China )

    Abstract Histological response or tumor necrosis rate to neoadjuvant chemotherapy has been shown to be associated with survival in osteosarcoma patients. Accurate and noninvasive detective methods to predict response to neoadjuvant chemotherapy would be important for planning surgery and adjustment subsequent therapy. This review summarizes recent advances in predicting response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles.

    KEY WORDSosteosarcoma; neoadjuvant chemotherapy; necrosis rate; gene chip

    骨肉瘤是青少年原发性恶性骨肿瘤中发病率最高的肿瘤[1- 2] ......