茵栀黄颗粒联合双歧杆菌三联活菌胶囊治疗新生儿高胆红素血症疗效观察(1)
摘 要 目的：观察茵栀黄颗粒联合双歧杆菌三联活菌胶囊治疗新生儿高胆红素血症的疗效。 方法：将高胆红素血症患儿依家长意愿分为两组，观察组予茵栀黄颗粒联合双歧杆菌三联活菌胶囊口服，对照组予清肝利胆口服液口服，连服5 d，观察两组患儿经皮胆红素的变化。结果：观察组与对照组治疗5 d后，黄疸均较前减轻，但观察组疗效更显著，不良反应较对照组少。结论：茵栀黄颗粒联合双歧杆菌三联活菌胶囊治疗新生儿高胆红素血症疗效确切，不良反应较少。
关键词 茵栀黄颗粒 新生儿 高胆红素血症 双歧杆菌三联活菌胶囊
中图分类号：R725.5 文献标识码：B 文章编号：1006-1533(2015)05-0026-02
Observation of the efficacy of yinzhihuang particles combined with
, http://www.100md.com
bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia
ZHU Hongwen， ZHANG Lifei， ZHANG Huijuan
(Department of pediatrics， The Third People’S Hospital of Zhengzhou City， Zhengzhou 450009， China)
ABSTRACT Objective： To investigate the clinical efficacy of yinzhihuang particles combined with bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia. Methods： Newborn infants with hyperbilirubinemia were divided into an observation group and a control group based on the request of parents. Yinzhihuang particles combined with bifid triple viable capsule were given in the observation group while only Qinggan-Lidan decoction in the control group for 5 days. The efficacy and the changes of transcutaneous bilirubin measurement were observed and compared between the two groups. Results： The jaundice was all regressed in the two groups but the efficacy was more significant in the observation group than in the control group (P<0.05)， and the incidence of adverse reactions was less in the observation group than in the control group. Conclusion： The efficacy of Yinzhihuang particles combined with bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia is more effective with less adverse reactions.
, 百拇医药
KEY WORDS yinzhihuang; neonatal; hyperbilirubinemia; bifid triple
高胆红素血症是新生儿期常见症状，其严重并发症为胆红素脑病，可影响小儿的神经、精神、智力的发育，目前蓝光照射仍是治疗新生儿高未结合胆红素血症的主要方法之一。由于光疗时间长，易出现脱水、发热、腹泻、皮疹等不良反应，且治疗费用高，母婴分离，许多家长不能接受。我们用茵栀黄颗粒联合双歧杆菌三联活菌胶囊对一定病例门诊治疗，取得较好疗效，报道如下。
资料与方法
对象
选取2011年11月-2013年8月门诊治疗的新生儿高胆红素血症患儿(诊断标准符合《儿科学》[1])，目测皮肤为阳黄，大便为黄色，无母婴ABO、RH血型不合，且经皮测胆红素值≤250 μmol /L，无其他疾病，足月出生，依据家长意愿分为两组，观察组50例，其中男32例，女18例，日龄7～40 d，平均17.5 d，对照组30例，其中男18例，女12例，日龄8～38 d，平均日龄18 d，两组具可比性。
方法
观察组给予茵栀黄颗粒(鲁南厚普制药有限公司生产)，3 g/包，每次1 g，每日3次，联合双歧杆菌三联活菌胶囊(商品名：培菲康，上海信谊制药厂有限公司生产)，0.21 g/粒，每次1/2粒，每日3次，温水送服。对照组予清肝利胆口服液(广州香雪制药股份有限公司生产)，10 ml/支，每次1/3支，每日3次口服，用药5 d，治疗期间不停母乳，服药前及服药5 d后经皮测量新生儿的额部、颧部、前胸部，取三者平均值为测定结果，并记录患儿的不良反应表现。, http://www.100md.com(朱红文 张理斐 张慧娟)
关键词 茵栀黄颗粒 新生儿 高胆红素血症 双歧杆菌三联活菌胶囊
中图分类号：R725.5 文献标识码：B 文章编号：1006-1533(2015)05-0026-02
Observation of the efficacy of yinzhihuang particles combined with
, http://www.100md.com
bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia
ZHU Hongwen， ZHANG Lifei， ZHANG Huijuan
(Department of pediatrics， The Third People’S Hospital of Zhengzhou City， Zhengzhou 450009， China)
ABSTRACT Objective： To investigate the clinical efficacy of yinzhihuang particles combined with bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia. Methods： Newborn infants with hyperbilirubinemia were divided into an observation group and a control group based on the request of parents. Yinzhihuang particles combined with bifid triple viable capsule were given in the observation group while only Qinggan-Lidan decoction in the control group for 5 days. The efficacy and the changes of transcutaneous bilirubin measurement were observed and compared between the two groups. Results： The jaundice was all regressed in the two groups but the efficacy was more significant in the observation group than in the control group (P<0.05)， and the incidence of adverse reactions was less in the observation group than in the control group. Conclusion： The efficacy of Yinzhihuang particles combined with bifid triple viable capsule in the treatment of neonatal with hyperbilirubinemia is more effective with less adverse reactions.
, 百拇医药
KEY WORDS yinzhihuang; neonatal; hyperbilirubinemia; bifid triple
高胆红素血症是新生儿期常见症状，其严重并发症为胆红素脑病，可影响小儿的神经、精神、智力的发育，目前蓝光照射仍是治疗新生儿高未结合胆红素血症的主要方法之一。由于光疗时间长，易出现脱水、发热、腹泻、皮疹等不良反应，且治疗费用高，母婴分离，许多家长不能接受。我们用茵栀黄颗粒联合双歧杆菌三联活菌胶囊对一定病例门诊治疗，取得较好疗效，报道如下。
资料与方法
对象
选取2011年11月-2013年8月门诊治疗的新生儿高胆红素血症患儿(诊断标准符合《儿科学》[1])，目测皮肤为阳黄，大便为黄色，无母婴ABO、RH血型不合，且经皮测胆红素值≤250 μmol /L，无其他疾病，足月出生，依据家长意愿分为两组，观察组50例，其中男32例，女18例，日龄7～40 d，平均17.5 d，对照组30例，其中男18例，女12例，日龄8～38 d，平均日龄18 d，两组具可比性。
方法
观察组给予茵栀黄颗粒(鲁南厚普制药有限公司生产)，3 g/包，每次1 g，每日3次，联合双歧杆菌三联活菌胶囊(商品名：培菲康，上海信谊制药厂有限公司生产)，0.21 g/粒，每次1/2粒，每日3次，温水送服。对照组予清肝利胆口服液(广州香雪制药股份有限公司生产)，10 ml/支，每次1/3支，每日3次口服，用药5 d，治疗期间不停母乳，服药前及服药5 d后经皮测量新生儿的额部、颧部、前胸部，取三者平均值为测定结果，并记录患儿的不良反应表现。, http://www.100md.com(朱红文 张理斐 张慧娟)