摘 要 本文结合肺部的解剖学和生理学特征以及肺结核的病理学特征重点阐释了抗结核药物肺部递送的优势和应关注的问题。通过近几年若干肺部递送抗结核药物的研究实例说明了肺结核治疗的这一新途径的可行性。

    关键词 肺结核 肺部递送 巨噬细胞靶向 空气动力学直径

    中图分类号：R943； R521 文献标识码：A 文章编号：1006-1533(2016)17-0071-07

    A new direction for tuberculosis treatment— the pulmonary delivery of anti-tuberculosis drugs

    CHEN Xi*(Sichuan Nursing Vocational College， Chengdu 610100， China)

    ABSTRACT This review highlights the advantages of the pulmonary delivery of anti-TB agents and the associated concerns based on the understanding of the characteristics of both the anatomy and physiology of the lung and the TB pathology. The feasibility of this new drug delivery approach has been recently proven by some case-studies on the pulmonary delivery of anti-TB agents.

    KEY WORDS tuberculosis； pulmonary delivery； macrophage targeting； aerodynamic diameter

    肺结核是一种由空气中结核分枝杆菌引起的细胞内感染性疾病 ......