胸腺肽对50例复发性口腔溃疡患者的免疫球蛋白及T淋巴细胞亚群的影响(1)
摘 要 目的：探讨胸腺肽对复发性口腔溃疡患者的免疫球蛋白及T淋巴细胞亚群的影响。方法：选取复发性口腔溃疡患者100例，依据随机分配原则分为维生素组和胸腺肽组各50例。维生素组患者给予20 mg维生素B2 口服治疗，胸腺肽组患者在此基础上给予20 mg胸腺肽口服治疗。采用免疫酶法检测T淋巴细胞亚群(CD3、CD4、CD8)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平，随访1年，统计分析所有患者临床疗效、淋巴细胞转化率、红细胞玫瑰花环形成细胞率、T淋巴细胞亚群及不良反应发生情况。结果：治疗后，胸腺肽组患者治疗有效率、CD3、CD4、CD4/CD8、淋巴细胞转化率、红细胞玫瑰花环形成细胞率、IgA、IgG、IgM水平均明显高于维生素组(P<0.05)，而2组患者不良反应发生率无显著差异性(P>0.05)。结论：口服胸腺肽治疗可有效改善复发性口腔溃疡患者的免疫球蛋白及T淋巴细胞亚群水平，增强机体免疫力，提高患者的临床疗效，且具有良好的安全性，值得临床作进一步实践。
关键词 胸腺肽 复发性口腔溃疡 T淋巴细胞亚群
中图分类号：R979.5； R781.51 文献标识码：B 文章编号：1006-1533(2016)19-0031-03
Effect of thymosin on the levels of immunoglobulins and T lymphocyte subsets of 50 cases of patients with recurrent oral ulcer
CHEN Zhenxiang*， LUO Heping， ZHANG Jinping， XIONG Xiaoyan， YANG Fang(Department of Stomatology， The People’s Hospital of Pingxiang City， Pingxiang 337055， China)
ABSTRACT Objective： To discuss the effect of thymosin on immunoglobulin and T lymphocyte subsets of patients with recurrent oral ulcer. Methods： One hundred patients were selected and randomly divided into a vitamin group and a thymosin group with 50 cases each. The vitamin group was orally given 20 mg vitamin B2 while the thymosin group was orally given 20 mg thymosin besides 20 mg of vitamin B2. The levels of Immunoglobulins (IgA， IgG and IgM) and T lymphocyte subsets (CD3， CD4 and CD8) were detected by immunoenzyme method. All the patients were followed up for one year and their curative effectiveness， the lymphocyte conversion rate， erythrocyte rosette formation cell rate， T lymphocyte and adverse reactions were statistically analyzed. Results： The treatment efficiency， CD3， CD4， CD4/CD8 levels， lymphocyte conversion rate， erythrocyte rosette formation cell rate and immunoglobulin levels were higher in the thymosin group than in the vitamin group (P<0.05) after treatment. There were no prominent differences in the incidence of adverse reactions between two groups (P>0.05). Conclusion： Oral thymosin can improve the levels of immunoglobulins and T lymphocyte subsets of patients with recurrent oral ulcer， enhance immunity and improve clinical curative efficiency with good safety. So it is worthy of clinical further practice.
KEY WORDS thymosin； recurrent oral ulcer； T lymphocyte subsets
复发性口腔溃疡又称复发性阿弗他口炎，是临床上最常见的口腔疾病之一，可导致溃疡、烧灼感疼痛等症状，好发于唇、颊、舌缘等部位，影响患者的正常饮食，进而严重影响患者的身心健康[1]。目前，药物治疗是临床上治疗复发性口腔溃疡常用的手段之一，可有效缓解患者的临床症状，但由于其周期性、复发性、自限性等特征，仍有部分患者治疗后出现复发，导致疗效欠佳。有研究显示，通过改善复发性口腔溃疡患者免疫功能状态，可提高对患者的治疗疗效[2]。而有相关研究表明，胸腺肽可使失衡的免疫细胞恢复正常，进而改善患者的免疫功能，然而关于胸腺肽用于复发性口腔溃疡治疗及其对患者的免疫球蛋白及T淋巴细胞亚群的影响的研究较少[3]。对此，为了进一步提高患者的临床疗效，本研究通过给予患者胸腺肽治疗，探讨其对患者疗效、免疫球蛋白及T淋巴细胞亚群的影响。 (陈珍香 罗和平 张金萍 熊筱艳 杨芳)
关键词 胸腺肽 复发性口腔溃疡 T淋巴细胞亚群
中图分类号：R979.5； R781.51 文献标识码：B 文章编号：1006-1533(2016)19-0031-03
Effect of thymosin on the levels of immunoglobulins and T lymphocyte subsets of 50 cases of patients with recurrent oral ulcer
CHEN Zhenxiang*， LUO Heping， ZHANG Jinping， XIONG Xiaoyan， YANG Fang(Department of Stomatology， The People’s Hospital of Pingxiang City， Pingxiang 337055， China)
ABSTRACT Objective： To discuss the effect of thymosin on immunoglobulin and T lymphocyte subsets of patients with recurrent oral ulcer. Methods： One hundred patients were selected and randomly divided into a vitamin group and a thymosin group with 50 cases each. The vitamin group was orally given 20 mg vitamin B2 while the thymosin group was orally given 20 mg thymosin besides 20 mg of vitamin B2. The levels of Immunoglobulins (IgA， IgG and IgM) and T lymphocyte subsets (CD3， CD4 and CD8) were detected by immunoenzyme method. All the patients were followed up for one year and their curative effectiveness， the lymphocyte conversion rate， erythrocyte rosette formation cell rate， T lymphocyte and adverse reactions were statistically analyzed. Results： The treatment efficiency， CD3， CD4， CD4/CD8 levels， lymphocyte conversion rate， erythrocyte rosette formation cell rate and immunoglobulin levels were higher in the thymosin group than in the vitamin group (P<0.05) after treatment. There were no prominent differences in the incidence of adverse reactions between two groups (P>0.05). Conclusion： Oral thymosin can improve the levels of immunoglobulins and T lymphocyte subsets of patients with recurrent oral ulcer， enhance immunity and improve clinical curative efficiency with good safety. So it is worthy of clinical further practice.
KEY WORDS thymosin； recurrent oral ulcer； T lymphocyte subsets
复发性口腔溃疡又称复发性阿弗他口炎，是临床上最常见的口腔疾病之一，可导致溃疡、烧灼感疼痛等症状，好发于唇、颊、舌缘等部位，影响患者的正常饮食，进而严重影响患者的身心健康[1]。目前，药物治疗是临床上治疗复发性口腔溃疡常用的手段之一，可有效缓解患者的临床症状，但由于其周期性、复发性、自限性等特征，仍有部分患者治疗后出现复发，导致疗效欠佳。有研究显示，通过改善复发性口腔溃疡患者免疫功能状态，可提高对患者的治疗疗效[2]。而有相关研究表明，胸腺肽可使失衡的免疫细胞恢复正常，进而改善患者的免疫功能，然而关于胸腺肽用于复发性口腔溃疡治疗及其对患者的免疫球蛋白及T淋巴细胞亚群的影响的研究较少[3]。对此，为了进一步提高患者的临床疗效，本研究通过给予患者胸腺肽治疗，探讨其对患者疗效、免疫球蛋白及T淋巴细胞亚群的影响。 (陈珍香 罗和平 张金萍 熊筱艳 杨芳)