口腔正畸治疗对口腔中细菌微生态的影响(1)
摘 要 目的：探究口腔正畸治疗患者口腔中细菌微生态的变化情况。方法：抽取进行口腔正畸治疗的45例患者作为观察组，45例口腔健康群体作为对照组，取所有患者牙龈沟内液体予以细菌培养并进行对比分析。结果：正畸前，观察组牙龈沟细菌的分布情况、情况与对照组相比无显著差异，细菌类型主要是球菌与杆菌；正畸后1个月、3个月，观察组的球菌、杆菌所占比例减少，而螺旋体、梭状菌所占比例增加(P<0.05)；观察组核梭杆菌、卟啉单胞菌、伴放线放线杆菌、福塞氏类杆菌等口腔细菌的检出率以及碱性磷酸酶(ALP)活性显著高于对照组(P<0.05)。结论：口腔正畸能够改变口腔细菌微生态，提高ALP的水平以及活性，增加核梭杆菌、卟啉单胞菌、伴放线放线杆菌、福塞氏类杆菌的检出率，进而引起炎症反应。
关键词 口腔正畸 细菌微生态 ALP活性
中图分类号：R783.5 文献标识码：B 文章编号：1006-1533(2017)01-0044-03
Effects of orthodontic treatment on bacterial microecology in oral cavity
ZHOU Jiahui*
(Department of Stomatology， the People’s Hospital of Zhuhai City， Zhuhai 519000， China)
ABSTRACT Objective： To investigate the changes of bacterial microecology in oral cavity of patients undergoing orthodontic treatment. Methods： Forty-five cases of patients undergoing orthodontic treatment were selected as an observation group and 45 cases of orally healthy volunteers were selected as a control group. The bacterial cultures from gingival sulcus fluid of all patients were compared and analyzed. Results： Before orthodontic treatment， the distribution of gingival crevicular bacteria in the observation group showed no significant differences compared with that in the control group， and bacterial types were mainly cocci and bacilli. The proportion of cocci and bacilli in the observation group decreased， while the proportion of spirochete and fusiforms increased at a month and three months after treatment (P<0.05). The detection rate of oral bacteria including Fusobacterium nucleatum， Porphyromonas， Actinobacillus actinomycetem comitans and Bacteroides forsythus， and alkaline phosphatase (ALP) activity were significantly higher in the observation group than in the control group (P<0.05). Conclusion： Orthodontic treatment can change the oral microflora， and increase the level and activity of ALP as well as the detection rate of Fusobacterium gingivalis， Porphyromonas and Actinobacillus actinomycetem comitans， and Bacteroides forsythus， which can cause inflammation.
KEY WORDS orthodontic treatment； microecology； ALP activity
口腔正畸是治療错颌畸形患者主要的方法之一[1]，但由于正畸过程中矫治装置的使用会改变口腔内环境，从而导致口腔微生态环境发生变化，导致口腔及牙龈的生态失调，使口腔及牙龈的微生物的类型、微生物的数量等发生变化[2]。此外，使用矫治器的患者对牙齿的清洁较为困难，易使牙龈内的细菌变多，进而导致牙龈出现各种炎症问题，严重时还会发生放线菌的感染，增加临床治疗的难度[3]。为了了解进行口腔正畸的患者口腔内细菌微生态的变化情况，我院对此展开探究。
1 资料与方法
1 . 1 一般资料
随机抽取2014年5月—2016年5月间我院收治的进行口腔正畸治疗的患者45例作为观察组以及口腔健康的群体45例作为对照组。观察组中男20例，女25例，平均年龄(13.29±2.34)岁；对照组中男22例，女23例，平均年龄是(12.92±2.54)岁。 (周佳卉)
关键词 口腔正畸 细菌微生态 ALP活性
中图分类号：R783.5 文献标识码：B 文章编号：1006-1533(2017)01-0044-03
Effects of orthodontic treatment on bacterial microecology in oral cavity
ZHOU Jiahui*
(Department of Stomatology， the People’s Hospital of Zhuhai City， Zhuhai 519000， China)
ABSTRACT Objective： To investigate the changes of bacterial microecology in oral cavity of patients undergoing orthodontic treatment. Methods： Forty-five cases of patients undergoing orthodontic treatment were selected as an observation group and 45 cases of orally healthy volunteers were selected as a control group. The bacterial cultures from gingival sulcus fluid of all patients were compared and analyzed. Results： Before orthodontic treatment， the distribution of gingival crevicular bacteria in the observation group showed no significant differences compared with that in the control group， and bacterial types were mainly cocci and bacilli. The proportion of cocci and bacilli in the observation group decreased， while the proportion of spirochete and fusiforms increased at a month and three months after treatment (P<0.05). The detection rate of oral bacteria including Fusobacterium nucleatum， Porphyromonas， Actinobacillus actinomycetem comitans and Bacteroides forsythus， and alkaline phosphatase (ALP) activity were significantly higher in the observation group than in the control group (P<0.05). Conclusion： Orthodontic treatment can change the oral microflora， and increase the level and activity of ALP as well as the detection rate of Fusobacterium gingivalis， Porphyromonas and Actinobacillus actinomycetem comitans， and Bacteroides forsythus， which can cause inflammation.
KEY WORDS orthodontic treatment； microecology； ALP activity
口腔正畸是治療错颌畸形患者主要的方法之一[1]，但由于正畸过程中矫治装置的使用会改变口腔内环境，从而导致口腔微生态环境发生变化，导致口腔及牙龈的生态失调，使口腔及牙龈的微生物的类型、微生物的数量等发生变化[2]。此外，使用矫治器的患者对牙齿的清洁较为困难，易使牙龈内的细菌变多，进而导致牙龈出现各种炎症问题，严重时还会发生放线菌的感染，增加临床治疗的难度[3]。为了了解进行口腔正畸的患者口腔内细菌微生态的变化情况，我院对此展开探究。
1 资料与方法
1 . 1 一般资料
随机抽取2014年5月—2016年5月间我院收治的进行口腔正畸治疗的患者45例作为观察组以及口腔健康的群体45例作为对照组。观察组中男20例，女25例，平均年龄(13.29±2.34)岁；对照组中男22例，女23例，平均年龄是(12.92±2.54)岁。 (周佳卉)