清热利湿益肾解毒汤治疗HPV持续感染50例的临床疗效(1)
摘 要 目的：探討清热利湿益肾解毒汤治疗人乳头瘤病毒(HPV)持续感染的临床疗效。方法：对50例宫颈HPV持续感染患者的临床资料进行回顾性分析，将所有患者根据不同的治疗方法分为对照组和研究组各25例，对照组患者采用重组人干扰素-α2b凝胶治疗，研究组在对照组的基础上联合应用清热利湿益肾解毒汤治疗，比较两组患者的临床治疗效果、TCT异常率、HPV转阴率及治疗前后免疫功能、中医症候积分变化。结果：在治疗HPV持续感染的3个月、6个月、9个月中，研究组治疗总有效率均显著高于对照组(P<0.05)，随着治疗时间的延长，两组患者的TCT异常率显著减小，HPV转阴率显著增高，且研究组显著优于对照组(P<0.05)。治疗后两组患者的IFN-g、TNF-α水平明显升高，IL-10水平明显降低，且研究组升高及降低程度均显著优于对照组(P<0.05)。治疗前后两组患者的IL-4水平无明显变化，且组间比较无显著性差异，治疗后两组患者的中医症候均明显改善，且研究组改善程度显著优于对照组(P<0.05)。结论：对HPV持续感染患者采用清热利湿益肾解毒汤治疗能有效改善患者的临床症状，提高免疫功能，减少TCT异常，疗效安全可靠。
关键词 清热利湿益肾解毒汤 HPV持续感染 TCT异常率 HPV转阴率 免疫功能 中医症候
中图分类号：R512.99； R289.5 文献标识码：B 文章编号：1006-1533(2017)05-0021-04
Clinical effect of Qingre Lishi Yishen Jiedu decoction in the treatment of 50 cases of persistent HPV infection
CUI Li， XU Jing
(Department of Gynecology， Urumqi Hospital of Traditional Chinese Medicine， Xinjiang 830000， China)
ABSTRACT Objective： To explore the clinical effect of Qingre Lishi Yishen Jiedu decoction on persistent HPV infection. Methods： The clinical data from 50 cases of persistent HPV infection were retrospectively analyzed. All the patients were divided into a control group and a research group with 25 cases each according to the therapeutic method. The control group was treated with interferon α-2b gel and the research group with Qingre Lishi Yishen Jiedu decoction on the basis of control group. The clinical effect， abnormal rate of TCT， negative conversion rate of HPV and the changes of immune function and TCM symptom were compared between the two groups. Results： Total effective rates were higher in the research group than in the control group in the third， sixth and 9 ninth months after treatment (P<0.05). The abnormal rate of TCT was significantly reduced while the negative conversion rate of HPV was significantly increased with the extension of treatment time (P<0.05). The levels of IFN-g and TNF-α were increased while the level of IL-10 was obviously decreased after treatment and they were more significant in the research group than in the control group (P<0.05). The level of IL-4 showed no significant differences between the two groups before and after treatment (P>0.05). The TCM symptom was obviously improved in the two groups and furthermore its improvement was more significant in the research group than in the control group (P<0.05). Conclusion： The treatment of patients with persistent HPV infection with Qingre Lishi Yishen Jiedu decoction can improve the clinical symptoms and immune function and reduce the abnormal rate of TCT with safe and reliable efficacy. (崔莉 徐晶)
关键词 清热利湿益肾解毒汤 HPV持续感染 TCT异常率 HPV转阴率 免疫功能 中医症候
中图分类号：R512.99； R289.5 文献标识码：B 文章编号：1006-1533(2017)05-0021-04
Clinical effect of Qingre Lishi Yishen Jiedu decoction in the treatment of 50 cases of persistent HPV infection
CUI Li， XU Jing
(Department of Gynecology， Urumqi Hospital of Traditional Chinese Medicine， Xinjiang 830000， China)
ABSTRACT Objective： To explore the clinical effect of Qingre Lishi Yishen Jiedu decoction on persistent HPV infection. Methods： The clinical data from 50 cases of persistent HPV infection were retrospectively analyzed. All the patients were divided into a control group and a research group with 25 cases each according to the therapeutic method. The control group was treated with interferon α-2b gel and the research group with Qingre Lishi Yishen Jiedu decoction on the basis of control group. The clinical effect， abnormal rate of TCT， negative conversion rate of HPV and the changes of immune function and TCM symptom were compared between the two groups. Results： Total effective rates were higher in the research group than in the control group in the third， sixth and 9 ninth months after treatment (P<0.05). The abnormal rate of TCT was significantly reduced while the negative conversion rate of HPV was significantly increased with the extension of treatment time (P<0.05). The levels of IFN-g and TNF-α were increased while the level of IL-10 was obviously decreased after treatment and they were more significant in the research group than in the control group (P<0.05). The level of IL-4 showed no significant differences between the two groups before and after treatment (P>0.05). The TCM symptom was obviously improved in the two groups and furthermore its improvement was more significant in the research group than in the control group (P<0.05). Conclusion： The treatment of patients with persistent HPV infection with Qingre Lishi Yishen Jiedu decoction can improve the clinical symptoms and immune function and reduce the abnormal rate of TCT with safe and reliable efficacy. (崔莉 徐晶)