尤瑞克林联合丁苯酞对72例急性脑梗死患者血管内皮功能及神经功能的影响(1)
摘 要 目的：研究尤瑞克林联合丁苯酞治疗急性脑梗死的疗效及其对患者血管内皮功能及神经功能的影响。方法：选取144例急性脑梗死患者并随机均分为实验组和对照组。所有患者均接受常规支持治疗，对照组在此基础上予以尤瑞克林治疗，实验组予以尤瑞克林联合丁苯酞治疗。比较分析两组的临床疗效，患者治疗前后的血浆一氧化氮(NO)、内皮素-1(ET-1)含量及神经功能缺损评分。结果：治疗后，实验组的临床疗效优于对照组(P<0.05)；两组患者的血浆NO均明显升高，而血浆ET-1明显降低，并且实验组的NO含量高于对照组，ET-1含量低于对照组(P<0.05)；两组患者的NIHSS、CNFDS评分均明显下降，且实验组下降程度优于对照组(P<0.05)。两组安全性差异不显著。结论：尤瑞克林联合丁苯酞治疗急性脑梗死，能够有效改善患者血管内皮功能及神经功能，疗效显著。
关键词 急性脑梗死 尤瑞克林 丁苯酞 血管内皮功能 神经功能
中圖分类号：R743.33； R972.9 文献标识码：A 文章编号：1006-1533(2017)21-0016-03
Effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in 72 cases of patients with acute cerebral infarction
ZHUANG Qingfen， SU Weiqian
(Department of Encephalopathy， Traditional Chinese Medicine hospital of Quanzhou， Quanzhou 362000， China)
ABSTRACT Objective： To explore the effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in the treatment of patients with acute cerebral infarction. Methods： One hundred and forty-four cases with acute cerebral infarction were randomly divided into a research group and a control group. Besides the conventional therapy， the control group was treated with urinary kallikrein and the research group with urinary kallikrein plus butylphthalide. The clinical effects， plasma nitric oxide， content of ET-1 and neurological deficit score were compared between the two groups. Results： The clinical effects were better in the research group than in the control group after treatment (P<0.05). The content of plasma nitric oxide was improved and the content of ET-1 was decreased in the two groups. The content of plasma nitric oxide was higher while the content of ET-1 was significantly lower in the research group than in the control group (P<0.05). The NIHSS and CNFDS scores were all decreased in both groups and the decrease was more significant in the research group (P<0.05). There were no differences between the two groups in the incidence of adverse reactions. Conclusion： Urinary kallikrein plus butylphthalide for the treatment of patients with acute cerebral infarction can improve the endothelial and neurological functions with remarkable curative effect.
KEy WORDS acute cerebral infarction； urinary kallikrein； butylphthalide； endothelial function： neurological function
随着人们生活方式的改变，急性脑梗死已成为常见的脑血管疾病，全国每年新发脑卒中患者约200万人[1]。其致残率和致死率均较高，对患者的预后影响很大。急性脑梗死发病机制复杂，但临床尚无特效治疗方法，因而阻止缺血性脑损伤、促进恢复神经功能至关重要[2]。溶栓治疗可以快速改善缺血组织，但却容易受到治疗时间窗、颅内出血及再灌注损伤等方面因素的限制，因此运用药物进行积极的抗凝、抗血小板、保护神经和抗氧化等治疗尤为关键。本文主要根据我科的诊治经验，研究了尤瑞克林联合丁苯酞治疗急性脑梗死的疗效，以及其对患者血管内皮功能及神经功能的影响，具体报道如下。 (庄清芬 苏为谦)
关键词 急性脑梗死 尤瑞克林 丁苯酞 血管内皮功能 神经功能
中圖分类号：R743.33； R972.9 文献标识码：A 文章编号：1006-1533(2017)21-0016-03
Effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in 72 cases of patients with acute cerebral infarction
ZHUANG Qingfen， SU Weiqian
(Department of Encephalopathy， Traditional Chinese Medicine hospital of Quanzhou， Quanzhou 362000， China)
ABSTRACT Objective： To explore the effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in the treatment of patients with acute cerebral infarction. Methods： One hundred and forty-four cases with acute cerebral infarction were randomly divided into a research group and a control group. Besides the conventional therapy， the control group was treated with urinary kallikrein and the research group with urinary kallikrein plus butylphthalide. The clinical effects， plasma nitric oxide， content of ET-1 and neurological deficit score were compared between the two groups. Results： The clinical effects were better in the research group than in the control group after treatment (P<0.05). The content of plasma nitric oxide was improved and the content of ET-1 was decreased in the two groups. The content of plasma nitric oxide was higher while the content of ET-1 was significantly lower in the research group than in the control group (P<0.05). The NIHSS and CNFDS scores were all decreased in both groups and the decrease was more significant in the research group (P<0.05). There were no differences between the two groups in the incidence of adverse reactions. Conclusion： Urinary kallikrein plus butylphthalide for the treatment of patients with acute cerebral infarction can improve the endothelial and neurological functions with remarkable curative effect.
KEy WORDS acute cerebral infarction； urinary kallikrein； butylphthalide； endothelial function： neurological function
随着人们生活方式的改变，急性脑梗死已成为常见的脑血管疾病，全国每年新发脑卒中患者约200万人[1]。其致残率和致死率均较高，对患者的预后影响很大。急性脑梗死发病机制复杂，但临床尚无特效治疗方法，因而阻止缺血性脑损伤、促进恢复神经功能至关重要[2]。溶栓治疗可以快速改善缺血组织，但却容易受到治疗时间窗、颅内出血及再灌注损伤等方面因素的限制，因此运用药物进行积极的抗凝、抗血小板、保护神经和抗氧化等治疗尤为关键。本文主要根据我科的诊治经验，研究了尤瑞克林联合丁苯酞治疗急性脑梗死的疗效，以及其对患者血管内皮功能及神经功能的影响，具体报道如下。 (庄清芬 苏为谦)