摘 要 本文简要综述了维生素D3治疗肠易激综合征(IBS)的最新进展以及可能涉及的潜在机制。Vit D3/VDR信号通路在维持肠黏膜免疫耐受方面起着重要作用。随着对Vit D3研究的日益深入，Vit D3有望作为一种新型的安全有效的免疫调节剂，在IBS的治疗中发挥重要的作用。

    关键词 维生素D3 维生素D受体 树突状细胞 免疫调节剂

    中图分类号：R574.4； R977.24 文献标志码：A 文章编号：1006-1533(2018)07-0039-04

    The update of vitamin D3 in the treatment of irritable bowel syndrome

    CHEN Jian*， LUO Zhongguang， QIU Zhibing

    (Department of Digestive Disease， Huashan Hospital， Fudan University， Shanghai 200040， China)

    ABSTRACT The present paper briefly reviews the recent progress of vitamin D3 in the treatment of irritable bowel syndrome (IBS) and its potential mechanisms involved. The signaling pathway of vitamin D3 and vitamin D receptor plays an important role in maintaining the immune stability within intestinal mucosa. Vitamin D3 will be expected to be a novel immunomodulator in the treatment of IBS with the increasingly deeper research on vitamin D3.

    KEy WORDS vitamin D3； vitamin D receptor； dendritic cell； immunomodulator

    腸易激综合征(irritable bowel syndrome ......