肉桂多酚对急性酒精性肝损伤的保护作用
摘 要 目的：探究肉桂多酚对急性酒精性肝损伤的保护作用。方法：将54只昆明中小鼠随机平均分为6组：正常组、模型组、阳性对照组(400 mg/kg)和肉桂多酚低、中、高剂量组(150、300、600 mg/kg)，试验第14天模型组及各剂量组通过一次灌胃给予50度白酒(14 mg/kg)，正常组予以相同剂量蒸馏水建立急性酒精性肝损伤模型，测定各组小鼠血清中AST、ALT、MDA及SOD含量，计算肝脏指数并观察肝脏组织病理学变化。结果：与模型组相比，高、中、低剂量组中血清AST含量降低，SOD活性增强(P<0.05或P<0.01)，肝组织病理学改变减轻；仅高、中剂量组中血清ALT、MDA含量显著降低(P<0.05或P<0.01)。结论：肉桂多酚对急性酒精性肝损伤有保护作用。
关键词 肉桂多酚 急性酒精性肝损伤 保护
中图分类号：R965； R595.6 文献标志码：A 文章编号：1006-1533(2020)03-0065-04
Protective effect of cinnamon polyphenols on acute alcoholic liver injury*
XU Zexi1**， CHEN Liqin1， LU Weina1， LUO Qichen1， ZHUANG Xiaoyu1， HUANG Qiuchan1， LI Ganfeng1， XIAO Qing2***
(1. the Second Clinical College， Guangzhou Medical University， Guangzhou 511436， China； 2. College of Pharmacy， Guangzhou Medical University， Guangzhou 511436， China)
ABSTRACT Objective： To investigate the protective effect of cinnamon polyphenol on acute alcoholic liver injury. Methods： Fifty-four Kunming mice were randomly and averagely divided into 6 groups： blank group， model group， positive control group(400 mg/kg)and cinnamon polyphenol low， medium and high dose groups (150， 300， 600 mg/kg， respectively). Every-dosage group was intragastrically administered with one dose of 50 degrees liquor (14 mg/kg) on the 14th day while the blank group was given the same dose of distilled water so as to establish a model of acute alcoholic liver injury. The serum contents of AST， ALT， MDA and SOD were determined， liver index was calculated and the histopathologic changes of the hepatic tissue were observed in each group. Results： Compared with the model group， the serum contents of AST were decreased and the activity of SOD was increased among high， middle and low dose groups (P<0.05 or P<0.01)， and the pathological changes of liver were alleviated as well. However， only the contents of ALT and MDA in serum were significantly reduced in both high and middle groups (P<0.05 or P<0.01). Conclusion： Cinnamon polyphenol has protective effect on acute alcoholic liver injury.
KEY WORDS cinnamon polyphenols； acute alcoholic liver injury； protection
酒精性肝病(ALD)是由于長期的大量饮酒导致的常见的肝脏疾病。酒精肝的发病率与生活水平的提高密切相关。近年来，随着我国人民生活水平逐年的提高，酒精肝的发病率也逐年上升趋势[1]。急性酒精性肝损伤是ALD的早期表现，酒精及其代谢产物会引起脂质代谢紊乱、氧化应激及细胞凋亡等，对肝组织造成损害[2-3]。
肉桂为樟科植物肉桂树的干树皮，具有温中补肾，祛寒止痛的功能。近几年来国内外的药理研究发现，肉桂的活化成分有降血糖、抗氧化、抗肿瘤以及神经保护等作用。肉桂多酚是从肉桂皮提取的多酚类物质，目前已鉴定出肉桂多酚主要为类黄酮类及其多聚体化合物，有着抗氧化改善肝细胞的作用[4]。研究表明，黄酮类化合物对于保护急性肝损伤有着良好的效果[5]。本实验主要研究肉桂多酚对急性酒精肝损伤的保护功能以及可能的作用机制，为肉桂多酚解酒护肝的作用的研究提供一定的理论基础和实验依据。, http://www.100md.com(徐泽曦 陈丽琴 卢伟娜 罗琪琛 庄小玉 黄秋婵 李淦峰 肖青)
关键词 肉桂多酚 急性酒精性肝损伤 保护
中图分类号：R965； R595.6 文献标志码：A 文章编号：1006-1533(2020)03-0065-04
Protective effect of cinnamon polyphenols on acute alcoholic liver injury*
XU Zexi1**， CHEN Liqin1， LU Weina1， LUO Qichen1， ZHUANG Xiaoyu1， HUANG Qiuchan1， LI Ganfeng1， XIAO Qing2***
(1. the Second Clinical College， Guangzhou Medical University， Guangzhou 511436， China； 2. College of Pharmacy， Guangzhou Medical University， Guangzhou 511436， China)
ABSTRACT Objective： To investigate the protective effect of cinnamon polyphenol on acute alcoholic liver injury. Methods： Fifty-four Kunming mice were randomly and averagely divided into 6 groups： blank group， model group， positive control group(400 mg/kg)and cinnamon polyphenol low， medium and high dose groups (150， 300， 600 mg/kg， respectively). Every-dosage group was intragastrically administered with one dose of 50 degrees liquor (14 mg/kg) on the 14th day while the blank group was given the same dose of distilled water so as to establish a model of acute alcoholic liver injury. The serum contents of AST， ALT， MDA and SOD were determined， liver index was calculated and the histopathologic changes of the hepatic tissue were observed in each group. Results： Compared with the model group， the serum contents of AST were decreased and the activity of SOD was increased among high， middle and low dose groups (P<0.05 or P<0.01)， and the pathological changes of liver were alleviated as well. However， only the contents of ALT and MDA in serum were significantly reduced in both high and middle groups (P<0.05 or P<0.01). Conclusion： Cinnamon polyphenol has protective effect on acute alcoholic liver injury.
KEY WORDS cinnamon polyphenols； acute alcoholic liver injury； protection
酒精性肝病(ALD)是由于長期的大量饮酒导致的常见的肝脏疾病。酒精肝的发病率与生活水平的提高密切相关。近年来，随着我国人民生活水平逐年的提高，酒精肝的发病率也逐年上升趋势[1]。急性酒精性肝损伤是ALD的早期表现，酒精及其代谢产物会引起脂质代谢紊乱、氧化应激及细胞凋亡等，对肝组织造成损害[2-3]。
肉桂为樟科植物肉桂树的干树皮，具有温中补肾，祛寒止痛的功能。近几年来国内外的药理研究发现，肉桂的活化成分有降血糖、抗氧化、抗肿瘤以及神经保护等作用。肉桂多酚是从肉桂皮提取的多酚类物质，目前已鉴定出肉桂多酚主要为类黄酮类及其多聚体化合物，有着抗氧化改善肝细胞的作用[4]。研究表明，黄酮类化合物对于保护急性肝损伤有着良好的效果[5]。本实验主要研究肉桂多酚对急性酒精肝损伤的保护功能以及可能的作用机制，为肉桂多酚解酒护肝的作用的研究提供一定的理论基础和实验依据。, http://www.100md.com(徐泽曦 陈丽琴 卢伟娜 罗琪琛 庄小玉 黄秋婵 李淦峰 肖青)