王恩康 袁建业

    摘 要 血清素再摄取转运体是色胺能系统中的重要分子，主要负责血清素的转运和再摄取。通过将编码SERT的基因slc6A4敲除，可构建不同种属的SERT敲除(SERT KO或slc6A4-/-或SERT-/-)的动物模型用于研究多种相关疾病。本综述总结了SERT KO动物的病理生理改变及其作为疾病模型在相关研究中的应用。

    关键词 血清素再摄取转运体 血清素 基因敲除 动物模型

    中图分类号：R363.21 文献标志码：A 文章编号：1006-1533(2021)11-0052-05

    Pathophysiological changes and application of serotonin transporter gene knockout animals*

    WANG Enkang**， YUAN Jianye***(Institute of Digestive Diseases； Longhua Hospital， Shanghai University of Traditional Chinese Medicine， Shanghai 200032， China)

    ABSTRACT Serotonin reuptake transporter (SERT) is an important molecule in the serotonergic system. It is responsible for the transmission and reuptake of serotonin. By knockout (KO) of SERT gene slc6A4， animal models of SERT KO (slc6A-/-or SERT-/-) in different species have been established for the studies of a series of related diseases. This review summarizes the pathophysiological changes of SERT KO animals and the applications of them as disease models in related studies.

    KEy WORDS serotonin reuptake transporter； serotonin； gene knockout； animal model ......