高君 侯毅 陈楠

    摘 要 目的：探讨替罗非班致极重度血小板减少症的临床特点、防治策略以及临床药师在其中发挥的作用。方法：查阅国内外文献，对1例替罗非班导致的极重度血小板减少症的病例进行分析。结果：患者在应用替罗非班24 h内出现血小板计数严重下降，降至1.00×109/L，伴穿刺部位瘀斑出血，及时停用替罗非班后，血小板计数于停药后第5天恢复至正常范围内。结论：应用替罗非班的1～24 h内应加强血小板监测以及出血情况监护。临床药师应协同临床医生关注使用此类药物的患者，对可能出现的风险进行严格监控。

    关键词 替罗非班 极重度血小板减少症 药品不良反应

    中图分类号：R973.2 文献标志码：B 文章编号：1006-1533(2021)11-0071-04

    Clinical pharmacist participation in a case of extreme severe thrombocytopenia induced by tirofiban

    GAO Jun1，2*， HOU Yi3， CHEN Nan1，2**[1. Department of Pharmacy， the Peoples Hospital of Henan University of Chinese Medicine (the Peoples Hospital of Zhengzhou)， Zhengzhou 450003， China； 2. the Fifth Clinical Medical College of Henan University of Chinese Medicine ， Zhengzhou 450003， China； 3. Department of Pharmacy， the Seventh Peoples Hospital of Zhengzhou， Zhengzhou 450000， China]

    ABSTRACT Objective： To discuss the characteristics， prevention and treatment strategies of extremely severe thrombocytopenia induced by tirofiban， and the role of clinical pharmacists in it. Methods： By reviewing domestic and foreign literature， the case of extremely severe thrombocytopenia caused by tirofiban was analyzed. Results： Extremely severe thrombocytopenia occurred within the 24 hours after application of tirofiban and his platelet counts dropped to 1.00×109/L ......