邢岩

    摘 要 Graves甲状腺功能亢进是一种自身免疫性疾病，其特点是自身抗体刺激甲状腺激素受体导致甲状腺组织增生、甲状腺激素合成分泌过多。Graves甲状腺功能亢进可以通过抗甲状腺药物、放射性碘131(131I)和手术切除等三种方式治疗。目前131I治疗Graves甲状腺功能亢进已经为临床普遍接受，全文从131I治疗Graves甲状腺功能亢进的原理、适应证、方法、安全性及与Graves眼病的关系等方面结合近期国内外指南和研究进展进行综述。

    关键词 Graves病；甲状腺功能亢进；放射性碘治疗；抗甲状腺药物

    中图分类号：R322.5+1 文献标志码：A 文章编号：1006-1533(2021)14-0003-04

    Research progress of radionuclide 131 iodine in the treatment of Graves hyperthyroidism

    XING Yan

    (Department of Nuclear Medicine of Shanghai First Peoples Hospital affiliated to School of Medicine of Shanghai Jiao Tong University， Shanghai 200080， China )

    ABSTRACT Graves hyperthyroidism is an autoimmune disease， which is characterized by autoantibodies that stimulate thyroid hormones leading to thyroid tissue hyperplasia and excessive thyroid hormone synthesis and secretion. Graves hyperthyroidism can be treated by antithyroid drugs， radioiodine-131 and surgical resection. At present， the treatment of Graves hyperthyroidism with radioiodine-131 has been generally accepted clinically. This article reviews the principles， indications， methods ......