顾鸣宇

    摘 要 桥本脑病是与自身免疫性甲状腺疾病相关的以神经系统为主要表现的罕见病，发病机制尚不明确，且临床表现多样，缺乏特异性，相关检查又缺乏特征性，因此容易漏诊和误诊。桥本脑病的主要临床表现包括认知功能障碍、短暂性失语、偏头痛、震颤、共济失调、癫痫发作、行为异常和情绪障碍等。绝大多数患者对糖皮质激素冲击疗法反应良好。全文从桥本脑病的临床表现、发病机制、诊断、治疗和预后方面进行简单论述。

    关键词 桥本脑病；自身免疫性；甲状腺抗过氧化物酶抗体；糖皮质激素

    中图分类号：R651.1+9 文献标志码：A 文章编号：1006-1533(2021)16-0006-03

    Hashimotos encephalopathy

    GU Mingyu

    (Department of Endocrinology and Metabolism of the First Peoples Hospital affiliated to Shanghai Jiao Tong University， Shanghai 200080， China)

    ABSTRACT Hashimotos encephalopathy is a rare disease with the main manifestation of the nervous system related to autoimmune thyroid disease， the pathogenesis is not clear， and the clinical manifestations are diverse， lack specificity， and related examinations lack characteristics， so it is easy to miss and misdiagnose. The main clinical manifestations of Hashimotos encephalopathy include cognitive dysfunction， transient aphasia， migraine， tremor， ataxia， seizures， abnormal behavior and mood disorders. The vast majority of patients respond well to glucocorticoid shock therapy. The clinical manifestations ......