李岩 刘瑞英

    摘 要 目的：探究心悦胶囊+硫酸氢氯吡格雷对急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)者炎性反应及氧化应激影响。方法：选择60例行PCI术治疗的AMI患者分为观察组(心悦胶囊+硫酸氢氯吡格雷片)和对照组(硫酸氢氯吡格雷片)各30例。比较2组炎症、氧化应激指标水平。结果：两组肿瘤坏死因子-a、丙二醛水平较治疗前降低，白介素-10、超氧化物歧化酶水平较治疗前升高，且观察组变化幅度较大(P<0.05)。结论：AMI患者行PCI術治疗后采用心悦胶囊联合硫酸氢氯吡格雷片治疗可以减轻炎症、氧化应激反应。

    关键词 急性心肌梗死 经皮冠状动脉介入治疗 心悦胶囊 硫酸氢氯吡格雷片 炎性反应 氧化应激

    中图分类号：R286； R542.22 文献标志码：B 文章编号：1006-1533(2021)23-0061-03

    Effect of Xinyue capsules combined with clopidogrel hydrogen sulphate tablets on inflammatory reaction and oxidative stress in patients with acute myocardial infarction after percutaneous coronary intervention

    LI Yan1， LIU Ruiying2

    (1. Department of Pharmacy； 2. Department of Cardiology， the People’s Hospital of Yingtan City， Yingtan 335000， China)

    ABSTRACT Objective： To explore the effect of Xinyue capsule combined with clopidogrel hydrogen sulphate tablets on inflammatory response and oxidative stress in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods： Sixty patients with AMI treated with PCI were selected as an observation group (Xinyue capsule+ clopidogrel bisulfate tablets) and a control group (clopidogrel bisulfate tablets) with 30 cases each based on random number table. The inflammatory indicators and oxidative stress indicators were compared between the two groups. Results： Tumor necrosis factor-α and malondialdehyde levels were lower and interleukin-10 and superoxide dismutase levels were higher after treatment than before in the two groups ......