张慧 姚慧慧 谢远丝

    摘 要 目的：探讨精神运动康复结合舍曲林治疗抑郁障碍的疗效与安全性。方法：将80例抑郁障碍患者按入组的先后顺序分为对照组(舍曲林50～200 mg/d)和研究组(舍曲林50～200 mg/d+精神运动康复治疗)各40例。治疗8周后，对比两组的临床疗效和安全性。结果：两组患者治疗后各时间点的汉密尔顿抑郁量表(Hamilton’s depression scale， HAMD)评分均较治疗前降低，研究组评分低于对照组(P<0.05)；研究组最终临床疗效优于对照组(P<0.05)。两组治疗后各时间点不良反应量表(treatment emergent symptom scale， TESS)评分均无明显差异(P>0.05)。结论：精神运动康复结合舍曲林治疗抑郁障碍疗效显著，安全性高。

    关键词 精神运动康复 舍曲林 抑郁障碍 疗效 安全性

    中图分类号：R749.059； R749.92 文献标志码：B 文章编号：1006-1533(2022)01-0031-03

    基金项目：2019年东莞市社会科技发展一般项目(201950715006338)

    Efficacy and safety of psychomotor rehabilitation combined with sertraline in the treatment of depressive disorder

    ZHANG Hui， YAO Huihui， XIE Yuansi

    (Dongguan Mental Health Center， Dongguan 523016， China)

    ABSTRACT Objective： To investigate the efficacy and safety of psychomotor rehabilitation combined with sertraline in the treatment of depressive disorder. Methods： Eighty patients with depression were divided into a control group (sertraline 50-200 mg/d) and a study group (sertraline 50-200 mg/d plus psychomotor rehabilitation). Clinical efficacy and safety were compared between the two groups after 8 weeks of treatment. Results： The scores of Hamilton’s depression scale (HAMD) in both groups were lower after treatment than before and furthermore were lower in the study group than the control group (P<0.05) ......