付兆鑫 刘中柱 郑奕楠

    摘 要 黄芪甲苷是中药黄芪的主要活性成分之一，研究证实具有抗氧化应激、抗炎、抗纤维化等作用，近年来研究发现黄芪甲苷与肾脏疾病的治疗关系密切，也与糖尿病肾病、慢性肾小球肾炎、高血压肾病、肾肿瘤、急性肾损伤等肾脏疾病具有相关性。本文简述黄芪甲苷与肾脏疾病的相关性。

    关键词 黄芪甲苷 肾脏疾病 糖尿病肾病 急性肾损伤

    中图分类号：R285.5； R256.5 文献标志码：A 文章编号：1006-1533(2022)05-0043-03

    引用本文 付兆鑫， 刘中柱， 郑奕楠. 黄芪甲苷治疗肾脏疾病的研究进展[J]. 上海医药， 2022， 43(5)： 43-45； 57.

    Research progress in the astragaloside Ⅳ for the treatment of nephropathy

    FU Zhaoxin1，2， LIU Zhongzhu1， ZHENG Yi’nan2

    (1. the First Hospital affiliated to Jiamusi University， Jiamusi 154000， China； 2. School of Clinical Medicine， Jiamusi University， Jiamusi 154007， China)

    ABSTRACT Astragaloside Ⅳ (AS-Ⅳ) is one of the main active ingredients in the traditional Chinese medicine astragalus. Studies have shown that it has the effects of anti-oxidative stress， anti-inflammatory and anti-fibrosis. In recent years， studies have found that AS-Ⅳ is closely related to the treatment of kidney disease and is also related to diabetic nephropathy， chronic glomerulonephritis， hypertensive nephropathy， renal tumors， acute kidney injury and other kidney diseases. This article briefly describes the relationship between AS-Ⅳ and kidney disease. ......