马懿辰 肖以钦 陆肇曾

    摘 要 肢端肥大症是成年人因体内生长激素分泌过多而引起的一种内分泌代谢疾病，以血浆中生长激素和胰岛素样生长因子-1的水平显著增高为主要血清学标志。由于体内生长激素和胰岛素样生长因子-1的靶器官分布广泛，故肢端肥大症常会导致患者出现多系统功能异常。角膜、脉络膜和视网膜上也存在着生长激素受体。因此，肢端肥大症患者会有多种眼部改变。本文概要介绍肢端肥大症对眼部结构的影响及其与眼科相关疾病的关联。

    关键词 肢端肥大症 眼部 生长激素 胰岛素样生长因子-1 光学相干断层扫描

    中图分类号：R584.11； R771.3 文献标志码：A 文章编号：1006-1533(2022)07-0013-07

    引用本文 马懿辰， 肖以钦， 陆肇曾. 肢端肥大症对眼部的影响[J]. 上海医药， 2022， 43(7)： 13-19.

    Effects of acromegaly on the eye

    MA Yichen， XIAO Yiqin， LU Zhaozeng

    (Department of Ophthalmology， Huashan Hospital， Fudan University， Shanghai 200040， China)

    ABSTRACT Acromegaly is an endocrine and metabolic disease caused by excessive secretion of growth hormone (GH) in adults and its main serological markers are the marked elevation of the levels of GH and insulin-like growth factor-1 (IGF-1) in plasma. Due to the wide distribution of target organs of GH and IGF-1 in the whole body， acromegaly often leads to functional abnormalities of multiple systems. Growth hormone receptors are also present on the cornea， choroid and retina. Therefore， patients with acromegaly have a variety of ocular changes. This article briefly introduces the impact of acromegaly on ocular structure and its association with ophthalmology-related diseases. ......