活动性肺结核患者基质金属蛋白酶-9和血管内皮细胞生长因子在血清中的表达及其临床意义(1)
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【摘要】目的: 探讨基质金属蛋白酶-9(matrix metalloproteinase-9, MMP-9)及血管内皮细胞生长因子(vascular endothelial growth factor, VEGF)在活动性肺结核患者中的表达及其临床意义。方法: 采用ELISA方法检测42例活动性肺结核患者及42例健康人血清中MMP-9、VEGF表达水平。结果:活动性肺结核患者血清MMP-9、VEGF水平显著高于健康对照者(P<0.001);痰结核杆菌涂片阳性患者血清中MMP-9、VEGF水平显著高于涂片阳性患者(P<0.001);肺内广泛病变患者血清中MMP-9、VEGF水平显著高于肺内局限病变患者(P<0.001)。结论: MMP-9、VEGF的表达水平可能与活动性肿结核的发生发展有关,并且与肺结核临床特点密切相关。
【关键词】肺结核;基质金属蛋白酶-9;血管内皮细胞生长因子
Investigation of the serum MMP-9 and VEGF and its role in active pulmonary tuberculosis patients
HE QinWei
【Abstract】Objective To study the relationship between the serum expression of MMP-9 and VEGF with the clinical characteristics in active pulmonary tuberculosis patients. Methods Expression of MMP-9 and VEGF were detected by ELISA method in 42 patients with active pulmonary tuberculosis and with a control of 42 health cases. Results The serum levels of MMP-9 and VEGF in active pulmonary tuberculosis patients were significantly higher than that of healthy group(P<0 ......
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