托吡酯预防性治疗偏头痛血药浓度与临床疗效的分析(1)
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2010年8月1日
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【摘要】目的:探讨托吡酯预防性治疗偏头痛血药浓度与临床疗效的相关性研究。方法:将136例偏头痛患者随机分为托吡酯组(观察组)68例,阿米替林组(对照组)68例。观察上述两组治疗前后头痛指数和3个月内平均每日头痛的次数、天数、头痛强度及频率的变化。结果:观察组和对照组患者的头痛指数较治疗前有非常明显降低(P<0.01),在预防成人偏头痛发作方面疗效两组无显著差别,而两组在疗效与偏头痛患者的病程无显著性差别。结论:托吡酯100mg/d可有效预防成人偏头痛患者的偏头痛发作,且副作用轻微易耐受,安全性高是成人偏头痛发作预防性治疗的理想药物。
【关键词】托吡酯;阿米替林;偏头痛;预防
doi:10.3969/j.issn.1006-1959.2010.08.210文章编号:1006-1959(2010)-08-2181-03
Analysis of topiramate preventive treatment migraine serum concentration and clinical efficacyLIANG Ying-Zi1,WU Jie21.Department of Medicament Section,Danzao Hospital of Nanhai District of Foshan,Foshan 528216 Guangdong;2.Department of Medicament Section,Jinsha Hospital of Nanhai District of Foshan Foshan 528200 Guangdong
【Abstract】Objective:To investigate the related research of the preventive treatment of topiramate migraine serum concentration and clinical efficacy.Methods:136 cases of migraine patients were randomly divided into topiramate group (observation group) 68 cases,68 cases were amitriptyline (control group).To observe the above-mentioned two groups treatment before and after the headache index,and in 3 months the average daily number of headache,the number of days, headache intensity and the changes of frequency.Results:Topiramate group and amitriptyline group of patients with headache index before treatment have a very significantly lower (P<0.01),in the prevention aspects of adult migraine effect was no significant difference between the two groups,while the two groups in terms of curative effects in patients with migraine The course was no significant difference.Conclusion:Topiramate 100mg/d can be effective in preventing migraine adult patients with migraine,and minor side-effects of easy tolerance,high safe is adult patients with migraine preventive,it is ideal drug for treatment.
【Key words】Tpiramate;Amitriptyline;Migraine;Prevention
偏头痛的发病机理尚不清楚,目前认为是神经一血管功能障碍所致,主要诱发因素为脑血管平滑肌细胞内钙离子浓度增高,细胞钙超载,诱使血小板凝集并释放5-羟色胺(5-HT),使颅内血管痉挛,继而颅内、外较大动脉反应性扩张而引起头痛等临床症状[1]。在安静、黑暗环境内休息或睡觉后会得到缓解,但复发率高,不易根治[2]。偏头痛是常见病和多发病,根据全国流行病学调查报告,患病率985.2/10万,年发病率79.7/10万[3]。美国的流行病学调查显示慢性偏头痛的患病率约为1.3%[4],目前我国尚没有这方面的流行病学资料 ......
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