持续气道正压通气治疗对阻塞性睡眠呼吸暂停综合征患者血清IL-6和hs-CRP水平影响(1)
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【摘要】目的:通过研究阻塞性睡眠呼吸暂停综合征(OSAS)患者血清白细胞介素-6(IL-6)和超敏C反应蛋白(hs-CRP)的水平以及经持续气道正压通气(CPAP)治疗前后的水平变化,探讨IL-6和hs-CRP在OSAS患者发病机制及病理生理中的作用。方法:①新近诊断为OSAS患者62例及正常对照32例,所有观察对象于晨起采集静脉血标本,采用放射免疫分析法检测血清IL-6、散射比浊法检测血清hs-CRP水平。比较OSAS组与对照组间血清IL-6、hs-CRP水平的差异;②分析OSAS患者血清IL-6、hs-CRP水平与睡眠呼吸暂停低通气指数(AHI)和最低血氧饱和度的相关性;③OSAS组患者进行CPAP治疗3个月后复查上述各项指标,比较CPAP治疗前后血清IL-6、hs-CRP水平变化。结果:⑴OSAS组患者血清IL-6和hs-CRP水平分别为(128.38±36.62)pg/ml,(3.56±1.47)mg/l。较对照组升高(97.49±26.74)pg/ml,(2.17±1.06)mg/l,差异有统计学意义(P<0.01);⑵OSAS患者血清IL-6和hs-CRP水平与其AHI相关系数分别为0.599(P<0.01),0.497(P<0.01),呈正相关。OSAS患者血清IL-6和hs-CRP水平与其最低血氧饱和度相关系数分别为-0.583(P<0.05),-0.532(P<0.05),呈负相关;⑶OSAS患者进行CPAP治疗3个月后,回访53例,再次测定血清IL-6、hs-CRP水平,分别为(104.53±26.74)pg/ml,(2.65±1.22)mg/l,较治疗前减低,差异有统计学意义(P<0.01)。结论:OSAS患者血清IL-6、hs-CRP水平较正常升高,这可能是OSAS患者合并心脑血管疾病的原因之一,CPAP治疗能有效地降低OSAS患者的血清IL-6及hs-CRP水平。
【关键词】阻塞型睡眠呼吸暂停综合征;白细胞介素-6;超敏C反应蛋白持续气道正压通气
doi:10.3969/j.issn.1006-1959.2010.09.014文章编号:1006-1959(2010)-09-2312-02
Effect of Continuous Positive Airway Pressure Treatment on Serum Levels of IL-6 and hs-CRP in Patients With Obstructive Sleep Apnea SyndromeZHEN Guo-cui1,LUP Zhi-yang1,DONG Wei2,LI Min-jing1,LONG Qin1,LIU Chun-xia11.Department of Respiratory,Sleep Disorder Assessment Laboratory,The First People's Hospital of Foshan,Foshan,Guangdong 528000;2.Wanlong Hospital,Sihui,Zhaoqing,Guangdong 526200
【Abstract】Objective:To explore the changes of serum interleukin-6(IL - 6) and high-sensitivity C-reactive protein (hs-CRP) levels and the effect of continuous positive airway pressure(CPAP) therapy in patients with obstructive sleep apnea syndrome (OSAS).Methods:Serum levels of IL-6 and hs-CRP were measured in 62 patients with newly diagnosed OSAS both before and after CPAP therapy as well as in 32 controls.Results:Before CPAP therapy,serum levels of IL-6 and hs-CRP in patients with OSAS were obviously increased than those in control subjects(128 ......
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