乳腺浸润性小叶癌中HSP90α的表达及其预后的研究(1)
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【摘要】目的:探讨热休克蛋白90α(HSP90α)在乳腺浸润性小叶癌(ILC)组织中的表达,及其与ILC的临床病理特征以及预后的关系。方法:采用免疫组织化学法检测10例正常乳腺组织、56例ILC组织及其癌旁组织中HSP90α的表达。结果:在ILC组织中HSP90α的表达阳性率(73.2%)明显高于正常乳腺组织(10%)和癌旁组织(46.4%),具有显著性差异(P<0.05)。ILC组织中HSP90α的表达阳性率与累及浆膜情况、淋巴结转移状况及临床分期显著相关(P<0.05);但与患者年龄、有无远处转移及是否为多灶性肿瘤无关(P>0.05)。HSP90α表达阴性的ILC患者和HSP90α表达阳性的ILC患者术后1、3、5年生存率分别为90.9%、59.1%、54.6%和79.0%、28.9%、15.8%,两组具有显著性差异(P<0.05)。结论:HSP90α在乳腺浸润性小叶癌中的表达可能成为判断乳腺浸润性小叶癌预后的重要指标之一。
【关键词】乳腺浸润性小叶癌;热休克蛋白90α;预后
doi:10.3969/j.issn.1006-1959.2010.09.018文章编号:1006-1959(2010)-09-2317-02
Study the Expression of Heat Shock Proteins 90αand Its Prognosis in Invasive lobular breast carcinomaTIAN Yang-bin1,FENG Xuan-ming1,HE Wen-dong21.Department of pathology,Panzhihua Center Hospital.Panzhihua 617067 Sichuan Province,China;2.Department of pathology,Dali Medical College,Dali 671000 Yunnan Province,China
【Abstract】Objective:To investigate the expression of heat shock proteins 90α(HSP90α) in Invasive lobular carcinoma(ILC) and the relationship between its expression and clinical significance of tumor and prognosis.Methods:The expression of HSP90α was detected by immunohistochemistry in 10 normal breast tissues and 56 ILC tissues and adjacent ILC tissues.Results:The positive expression rate of HSP90α in ILC tissues(73.2%) was higher compared with normal breast tissues(10%) and adjacent ILC tissues(46.4%),it was different(P<0.05).The positive expression of HSP90α in ILC was correlated with serosal condition,lymph node metastasis and clinical stage(P<0.05),but not to age and a distant transfer of tumor and tumor number(P>0.05).The survival rates of 1,3,5 years in HSP90α negative group were 90.9%,59.1%,54.6% and in HSP90α positive group were 79.0%,28.9%,15.8%,there was significant difference between the two groups(P<0.05).Conclusion:HSP90α cxpression in ILC may be used as an important survival predictor and prognosis of ILC.
【Key words】Invasive lobular breast carcinoma;Heat shock-proteins 90α;Prognosis
近年来,乳腺癌预后指标研究的重点集中于免疫组织化学和分子指标。某些指标显示出极佳的预后价值和临床诊断价值,但由于这些指标的检测方法尚未标准化,从而限制其在临床上的广泛应用 ......
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