摘要：目的评价盐酸米诺环素辅助治疗重度慢性牙周炎的临床疗效。方法20例重度慢性牙周炎患者，以超声洁治后1w为基线。同一患者的一侧牙随机设置为实验组，另一侧为对照组。结果治疗后2个月和4个月实验组与对照组的BI、PD和AL与基线比较均有明显下降，当基线PD≥6mm时，治疗后2个月和4个月实验组的临床指标改善优于对照组。结论盐酸米诺环素辅助超声龈下刮治和手工根面平整术可以提高治疗重度慢性牙周炎的疗效。

    关键词：牙周炎；盐酸米诺环素；龈下刮治

    Clinical Observation of Minocycline Hydrochloride in the Treatment of Severe Chronic Periodontitis

    LIU Jin-hai,LIU Ming-xuan,HUANG Min

    (The First Affiliated Hospital of Gannan Medical College,Ganzhou 341000,Jiangxi,China)

    Abstract：Objective To evaluate the clinical effects of minocycline hydrochloride in adjuvant treatment of severe chronic periodontitis. Methods20 patients with severe chronic periodontitis patients, in 1 weeks after ultrasonic scaling for baseline. The teeth were randomly arranged side of the same patient as the experimental group, the other side as control group. Results In 2 months and 4 months of the experiment group and the control group BI, PD and AL compared with baseline were significantly decreased after treatment, when the baseline PD ≥ 6mm, the clinical indexes of 2 months and 4 months of experimental group was better than the control group. ConclusionMinocycline hydrochloride assisted Ultrasonic Subgingival Scaling and root planing craft can improve the curative effect in the treatment of severe chronic periodontitis. ......