摘要：目的 观察地西他滨联合CHG方案诱导化疗由骨髓增生异常综合征转化的急性髓系白血病的疗效和安全性。方法 7例新确诊post MDS-AML患者接受地西他滨联合CHG方案诱导化疗。结果 4例获完全缓解，1例达到部分缓解，总有效率约为71.42%(5/7)。4例患者出现Ⅳ度骨髓抑制，重度骨髓抑制发生率为57.14%(4/7)。5例并发感染，感染率71.42%(5/7)，其中1例治疗无效死亡，化疗相关死亡率14.28%(1/7)。不良反应可见发热及胃肠道反应等。结论 地西他滨联合CHG的诱导方案对骨髓增生异常综合征转化的急性髓系白血病有效，且有效率高，严重骨髓抑制是常见并发症，不良反应可以耐受。

    关键词：地西他滨；CHG；骨髓增生异常综合征转化急性髓系白血病

    Curative Effect of Induction Chemotherapy for Patients with MDS-transformed Acute Myeloid Leukemia with Decitabine Combined with CHG Regimen

    YI Xue,YU Dan,ZHANG Ting,ZOU Liang

    (Wuhan Integrated Tcm and Western Medicine Hospital,Wuhan 430022,Hubei,China)

    Abstract：ObjectiveTo evaluate the induction chemotherapy effect and safety of decitabine combined with CHG regime for MDS-transformed acute myeloid leukemia (post MDS-AML).Methods7 patients with post MDS-AML were treated with decitabine combined with CHG regimen.Results4 patients achieved complete remission ......