摘要：目的 探讨破血化瘀、填精补髓法对大鼠脑出血血肿周围组织GSK-3β信号通路表达的影响。方法 应用WISTAR大鼠复制脑出血大鼠模型，观察破血填精法在改善脑出血大鼠神经功能缺损及大鼠血肿周围组织GSK-3β信号通路表达情况。结果 与模型组相比，阳性药和受试药各组大鼠在给药1d和3d后能明显改善大鼠神经系统体征，降低神经功能缺损评分；在给药第3、7、14d，与模型组比较，受试药高剂量和中剂量均明显增加了损伤脑区GSK-3β信号通路表达数量(P<0.05或P<0.01，P<0.05)。结论 破血填精法方剂能明显改善脑出血大鼠神经功能缺损；其作用机制可能为调高脑出血血肿周围损伤组织中GSK-3β信号通路表达有关。

    关键词：脑出血；GSK-3β；破血化瘀；填精补髓

    Abstract：Objecttive To investigate the effect of decoction of Poxue and Tianjing on the expression of brain derived neurotrophic factor GSK-3βand its receptor to the perihematomal tissue in experimental ICH Rats.Methods Using WISTAR rats as the model rats of cerebral hemorrhage.It is designed to observe the effect of the behavioristic index that how the Decoction of Poxue and Tianjing could improve the neurological deficit of the rats.There is also a experiment which is designed to observe the protein expression of GSK-3β.Results Compared with the model control group ......