摘要：目的 观察Eales病患者血浆内皮素-1(Endothelin-1，ET-1)水平，探讨其与Eales病的关系。方法 ①将所有受试对象(包括Eales病患者及正常对照组)进行常规的全身检查及眼科检查②荧光素眼底血管造影结果结合眼底检查确定Eales病的分期。③内皮素-1的测定采用放射免疫法。结果 ①患病组ET-1平均值高于正常对照组(P<0.05)，差别有统计学意义。②患病组新生血管前期组和新生血管期组ET-1平均值比较P>0.05，差别无统计学意义。③患病组中男性ET-1平均值比女性平均值含量高(P<0.05)，差别有统计学意义。④患病组ET-1与年龄成正相关。结论 Eales病的发生可能与血浆内皮素的水平增高有关，具体机制有待进一步探讨。

    关键词：Eales病；视网膜静脉周围炎；内皮缩血管肽类； 发病机制

    Abstract：Objective The study observes Eales patients plasma Endothelin-1 level and explores their relationship to Eales disease.Methods ①Have all subjects (including Eales patients and normal matched control group) accept the conventional body checks and ophthalmic examination.②FFA and ophthalmic examination determine the stage of Eales disease. ③Endothelin-1 tests use radioimmunoassay. Results ①The average of the patient group's ET-1 is higher than the control group (P< 0.05). The difference is significant in statistical significance. ②The average of the patient group's ET-1 are compared between the proliferative stage's and the non- proliferative stage's. The result shows P> 0.05. The difference is insignificant in statistical significance.③The average of the males' ET-1 in the patient group is higher than the females' (P < 0.05).The difference is significant in statistical significance.4. ET-1 is positive correlation with age in the patient group. Conclusion The level of plasma ET-1 is associated with the Eales disease. ......