血浆胱抑素C水平对糖尿病肾病早期诊断的临床意义(2)
本实验显示与健康人群比较,糖尿病人群中CysC水平明显增加(P<0.05);早期肾病组较单纯组亦有显著增加。同时该实验显示以以血浆CysC水平>15.0 umol/L作为高CysC为标准,早期肾病组高CysC患者所占比例显著增加。提示CysC是早期诊断早期糖尿病肾病的敏感指标,本实验的结果和有关的实验结果相似[4],但其进一步的临床意义需进一步讨论。由于本实验样本量较小,设计亦有不足之处,因此还需进一步的临床实验来明确两者的关系。
参考文献:
[1]Ritz E, Rychlík I, Locatelli F, et al. End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions[J]. Am J Kidney Dis,1999,34(5):795-808.
[2]Risch L1, Blumberg A, Huber A.Rapid and accurate assessment of glomerular filtration rate in patients with renal transplants using serum cystatin C[J].Nephrol Dial Transplant,1999 ,14(8):1991-1996.
[3]Feriozzi S,Germain DP,Di Vito R,et a1.Cystatin C as amarker of early changes of renal function in Fabry nephropathy[J]. J Nephrol,2007,20.(4):437-443.
[4]Bieniasz M1, Kwiatkowski A, Gozdowska J, et al.Is cystatin C valuable marker of glomerular filtration rate in living kidney donors after uninephrectomy?[J].Transplant Proc,2012 ,44(10):2910-2912.
编辑/周芸霏, http://www.100md.com(王凌旭)
参考文献:
[1]Ritz E, Rychlík I, Locatelli F, et al. End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions[J]. Am J Kidney Dis,1999,34(5):795-808.
[2]Risch L1, Blumberg A, Huber A.Rapid and accurate assessment of glomerular filtration rate in patients with renal transplants using serum cystatin C[J].Nephrol Dial Transplant,1999 ,14(8):1991-1996.
[3]Feriozzi S,Germain DP,Di Vito R,et a1.Cystatin C as amarker of early changes of renal function in Fabry nephropathy[J]. J Nephrol,2007,20.(4):437-443.
[4]Bieniasz M1, Kwiatkowski A, Gozdowska J, et al.Is cystatin C valuable marker of glomerular filtration rate in living kidney donors after uninephrectomy?[J].Transplant Proc,2012 ,44(10):2910-2912.
编辑/周芸霏, http://www.100md.com(王凌旭)