超声射频信号技术分析维持性血液透析患者颈动脉弹性功能的研究(1)
摘要:目的 应用超声射频信号血管内中膜分析(QIMT)、动脉硬度分析(QAS)技术研究维持性血液透析患者颈动脉血管功能进行评估,探讨其在透析患者。方法 选择在我院维持性血液透析患者67例,按透析过程中有无低血压的发生将透析组患者分为透析低血压组33例和非低血压组34例,另选取30例健康者为对照组,分别接受颈动脉超声检查,获取颈总动脉内中膜厚度(IMT)、僵硬度系数(α、β)、脉搏波速度(PWV)。结果 与对照组相比较,透析组血管僵硬度参数IMT、PWV、α、β均增高(P<0.05);透析低血压组血管僵硬度参数IMT、PWV、α、β较非低血压组增高更为显著(P<0.05)。结论 透析低血压是透析患者心血管功能的重要影响因素,其血管弹性功能减低更为明显。超声射频技术血管内中膜分析(QIMT)、动脉硬度分析(QAS)技术可以早期获取并分析维持血液透析患者颈动脉弹性功能。
关键词:超声技术;维持血液透析;颈动脉弹性
Abstract:Objective To study on the carotid arterial elasticity in the patients with maintenance hemodialysis(MHD) by using quality intima-media thickness(QIMT),quality arterial stiffness(QAS).Methods 67 patients with maintenance hemodialysis in our hospital were selected,and they were divided into hypotesion group(n=33)and non-hypotesion group(n=34) according to whether or not hemodialytic hyposion was present.30 healthy volunteers were selected as a control group.Ultrasound examination for the carotid artery was performed and some parameters were obtained,such as intima-meida thickness(IMT),stiffness index (α and β),pulse wave velocity (PWV). Results Compared with the control group,vascular stiffness parameter IMT, α,βand PWV were all increased(P<0.05);IDH group than in N-IDH group increased more significantly(P<0.05).Conclusion Hypotesion was one of the important factor which could influent the vascular sclerosis and,QIMT,QAS technology can be used in patients with maintenance hemodialysis to evaluate vascular sclerosis and carotid arterial elasticity.
, 百拇医药
Key words:Ultrasonography;Hemodialysis,Carotid arterial elasticity
1 资料与方法
1.1一般资料 选择2013年9月~2014年3月在我院接受维持性血液透析患者67例,全部病例均符合慢性肾功能不全尿毒症期(即血肌酐>707 μmol/L,肾小球滤过率<10 ml/min,临床有贫血、代谢性酸中毒及钙磷代谢紊乱等表现),已接受规律血液透析3个月以上并且能够耐受血流量>250 ml/min,近2月未出现感染症状,无活动性自身免疫疾病,近期未使用激素及细胞毒药物。根据有无透析低血压即透析3个月内至少1/3透析过程收缩压下降25%以上或低于100mmHg(1mmHg
=0.133kPa),分为透析低血压组33例,平均(59.03±11.17)岁,女性27例,男性6例;非低血压组34例,平均(53.51±12.08)岁,女性30例,男性4例;选择30例健康成人作为对照组,其中女性21例,男性9例,平均(51.60±19.64)岁,均为经临床检查基础代谢无异常。经检验尿毒症组与正常对照组年龄与性别无明显差异。透析前,低血压组与非低血压组两组血压无统计学差异。
, 百拇医药
1.2方法
1.2.1使用设备 应用MYLAB TWICE型彩色超声诊断仪,LA523探头(频率4~13 MHz)及PA230(频率1~4 MHz),配备相关技术及分析软件QIMT、QAS以及MYLAB分析平台。
1.2.2超声检测 血管超声检测:患者取仰卧位,头略偏向检查对侧,连接同步肢体导联心电图,将探头轻置于侧颈部,首先通过颈动脉长轴及短轴切面探查颈动脉内膜是否光滑及斑块情况,然后选择颈总动脉分叉近端2~3 cm处进行检查,短轴显示管腔最大径后将探头顺时针旋转90°显示长轴切面,待管壁显示最清晰时启动QIMT软件,取样框尽量垂直于管壁系统,自动描记连续6个心动周期内的颈动脉内-中膜厚度(IMT)并给出平均值标准差SD≤15时,冻结图像并存储;启动QAS软件测定颈总动脉管壁运动轨迹及弹性参数,SD≤30时冻结图像并存储,得出膨胀波曲线,采集患者颈总动脉脉搏波速度(PWV)及僵硬度系数α、β。
1.3统计学分析 所有数据应用统计软件SPSS 19.0进行统计学分析,计量资料用(x±s)表示,差异检验采用两样本t检验;P<0.05为差异有统计学意义。, http://www.100md.com(郇致福)
关键词:超声技术;维持血液透析;颈动脉弹性
Abstract:Objective To study on the carotid arterial elasticity in the patients with maintenance hemodialysis(MHD) by using quality intima-media thickness(QIMT),quality arterial stiffness(QAS).Methods 67 patients with maintenance hemodialysis in our hospital were selected,and they were divided into hypotesion group(n=33)and non-hypotesion group(n=34) according to whether or not hemodialytic hyposion was present.30 healthy volunteers were selected as a control group.Ultrasound examination for the carotid artery was performed and some parameters were obtained,such as intima-meida thickness(IMT),stiffness index (α and β),pulse wave velocity (PWV). Results Compared with the control group,vascular stiffness parameter IMT, α,βand PWV were all increased(P<0.05);IDH group than in N-IDH group increased more significantly(P<0.05).Conclusion Hypotesion was one of the important factor which could influent the vascular sclerosis and,QIMT,QAS technology can be used in patients with maintenance hemodialysis to evaluate vascular sclerosis and carotid arterial elasticity.
, 百拇医药
Key words:Ultrasonography;Hemodialysis,Carotid arterial elasticity
1 资料与方法
1.1一般资料 选择2013年9月~2014年3月在我院接受维持性血液透析患者67例,全部病例均符合慢性肾功能不全尿毒症期(即血肌酐>707 μmol/L,肾小球滤过率<10 ml/min,临床有贫血、代谢性酸中毒及钙磷代谢紊乱等表现),已接受规律血液透析3个月以上并且能够耐受血流量>250 ml/min,近2月未出现感染症状,无活动性自身免疫疾病,近期未使用激素及细胞毒药物。根据有无透析低血压即透析3个月内至少1/3透析过程收缩压下降25%以上或低于100mmHg(1mmHg
=0.133kPa),分为透析低血压组33例,平均(59.03±11.17)岁,女性27例,男性6例;非低血压组34例,平均(53.51±12.08)岁,女性30例,男性4例;选择30例健康成人作为对照组,其中女性21例,男性9例,平均(51.60±19.64)岁,均为经临床检查基础代谢无异常。经检验尿毒症组与正常对照组年龄与性别无明显差异。透析前,低血压组与非低血压组两组血压无统计学差异。
, 百拇医药
1.2方法
1.2.1使用设备 应用MYLAB TWICE型彩色超声诊断仪,LA523探头(频率4~13 MHz)及PA230(频率1~4 MHz),配备相关技术及分析软件QIMT、QAS以及MYLAB分析平台。
1.2.2超声检测 血管超声检测:患者取仰卧位,头略偏向检查对侧,连接同步肢体导联心电图,将探头轻置于侧颈部,首先通过颈动脉长轴及短轴切面探查颈动脉内膜是否光滑及斑块情况,然后选择颈总动脉分叉近端2~3 cm处进行检查,短轴显示管腔最大径后将探头顺时针旋转90°显示长轴切面,待管壁显示最清晰时启动QIMT软件,取样框尽量垂直于管壁系统,自动描记连续6个心动周期内的颈动脉内-中膜厚度(IMT)并给出平均值标准差SD≤15时,冻结图像并存储;启动QAS软件测定颈总动脉管壁运动轨迹及弹性参数,SD≤30时冻结图像并存储,得出膨胀波曲线,采集患者颈总动脉脉搏波速度(PWV)及僵硬度系数α、β。
1.3统计学分析 所有数据应用统计软件SPSS 19.0进行统计学分析,计量资料用(x±s)表示,差异检验采用两样本t检验;P<0.05为差异有统计学意义。, http://www.100md.com(郇致福)