降钙素原对急性一氧化碳中毒预后判断的临床意义(1)
摘要：目的 觀察血清降钙素原(procalcitonin， PCT)对急性一氧化碳( carbon monoxide CO )中毒迟发型脑病的早期诊断价值。方法 选取我院2014年1月～2016年3月收治的134例急性一氧化碳中毒患者，按血碳氧血红蛋白分10%～20%轻度中毒(A组)38例，血碳氧血红蛋白在20%～40%的中度中毒患者(B组)80例，血碳氧血红蛋白在40%～50%的重度中毒患者((C组))16例，同期选择健康体检者30例作为阴性对照组。采用日常生活能力量表(Activity of Daily Living Scale，ADL)与简易智力状态检查量表(Mini-Mental stalteemination，MMSE)检查患者神经功能与智力。观察三组患者血白细胞、中性粒细胞、白介素2(IL-2)、白介素6(IL-6)、白介素10(IL-10)。血清降钙素(PCT)的水平，分析轻、中、重度急性一氧化碳中毒迟发型脑病患者与IL-2、IL-6、IL-10、PCT相关性。结果 三组神经功能与智力评分结果有非常显著的统计学差异，神经功能与智力的分数值随着中毒程度的加重而显著降低(P<0.01)。三组白细胞总数、中性粒细胞、IL-2、IL-6、IL-10、PCT水平均与正常水平比有差异，但随着中毒程度的加重，IL-2、IL-6明显降低，白细胞、中性粒细胞、IL-10、PCT明显升高，三组除中性粒细胞没有统计学差异外，其它均有统计学差异(P<0.01)。IL-2、IL-6、IL-10与迟发型脑病的相关性没有统计学差异(P>0.05)，PCT与迟发型脑病的相关性有非常显著的统计学差异(P<0.01)。结论 轻、中、重度急性一氧化碳中毒迟发型脑病患者与PCT有极其显著的相关性，拟可以作为早期判断一氧化碳中毒迟发型脑病发生的指标。
, 百拇医药
关键词：急性一氧化碳中毒；迟发型脑病；血清降钙素原
Abstract：Objective To investigate early diagnosis of serum procalcitonin (procalcitonin， PCT) on delayed encephalopathy with acute carbon monoxide (CO) poisoning.Methods 134 patients with acute carbon monoxide poisoning from January 2014 ～March 2016 in our hospital were divided into 38 cases mild poisoning (A group)in 10% -20% carboxyhemoglobin of blood， 80 cases moderate poisoning (group B)in 20% -40% carboxyhemoglobin of the blood， 16 cases severe poisoning ((group C))in 40% to 50% carboxyhemoglobin of the blood of. 30 cases of healthy people was as a negative control group during the same period . neurological and intelligence of Patients were examined by Activity of Daily Living Scale(ADL) and the Mini-Mental State Examination (MMSE). The level of white blood cell， neutrophils， IL-2， IL-6， IL-10， PCT were observed and analyzed in patients of 3 groups. The relevance of patients with delayed encephalopathy of mild， moderate， severe acute carbon monoxide poisoning was analyzed with IL-2， IL-6， IL-10， PCT .Results Neurological and mental score in the three groups had very significant statistical difference， neurological and mental point value was significantly decreased with the severity of poisoning (P<0.01). WBC， neutrophils， IL-2， IL-6， IL-10， PCT were different with normal thatlevel， IL-2， IL-6 was significantly reduced， leukocytes， neutrophils， IL-10， PCT were increased significantly with the severity of poisoning， in addition to the neutrophils was not statistically significant(P> 0.05)， other were statistically significant (P<0.01).The correlation between delayed encephalopathy and IL-2， IL-6， IL-10 were not statistically significant (P> 0.05)， correlation between PCT and delayed encephalopathy had a very statistically significant difference (P<0.01). Conclusion The patients with delayed encephalopathy of mild， moderate， severe acute carbon monoxide poisoning and PCT have extremely significant correlation.This seems to be used as early indicators for delayed encephalopathy of carbon monoxide poisoning., 百拇医药(彭滨菲 黄小燕 陈海龙)
, 百拇医药
关键词：急性一氧化碳中毒；迟发型脑病；血清降钙素原
Abstract：Objective To investigate early diagnosis of serum procalcitonin (procalcitonin， PCT) on delayed encephalopathy with acute carbon monoxide (CO) poisoning.Methods 134 patients with acute carbon monoxide poisoning from January 2014 ～March 2016 in our hospital were divided into 38 cases mild poisoning (A group)in 10% -20% carboxyhemoglobin of blood， 80 cases moderate poisoning (group B)in 20% -40% carboxyhemoglobin of the blood， 16 cases severe poisoning ((group C))in 40% to 50% carboxyhemoglobin of the blood of. 30 cases of healthy people was as a negative control group during the same period . neurological and intelligence of Patients were examined by Activity of Daily Living Scale(ADL) and the Mini-Mental State Examination (MMSE). The level of white blood cell， neutrophils， IL-2， IL-6， IL-10， PCT were observed and analyzed in patients of 3 groups. The relevance of patients with delayed encephalopathy of mild， moderate， severe acute carbon monoxide poisoning was analyzed with IL-2， IL-6， IL-10， PCT .Results Neurological and mental score in the three groups had very significant statistical difference， neurological and mental point value was significantly decreased with the severity of poisoning (P<0.01). WBC， neutrophils， IL-2， IL-6， IL-10， PCT were different with normal thatlevel， IL-2， IL-6 was significantly reduced， leukocytes， neutrophils， IL-10， PCT were increased significantly with the severity of poisoning， in addition to the neutrophils was not statistically significant(P> 0.05)， other were statistically significant (P<0.01).The correlation between delayed encephalopathy and IL-2， IL-6， IL-10 were not statistically significant (P> 0.05)， correlation between PCT and delayed encephalopathy had a very statistically significant difference (P<0.01). Conclusion The patients with delayed encephalopathy of mild， moderate， severe acute carbon monoxide poisoning and PCT have extremely significant correlation.This seems to be used as early indicators for delayed encephalopathy of carbon monoxide poisoning., 百拇医药(彭滨菲 黄小燕 陈海龙)