乙型肝炎病毒感染伴肝功能异常肝功能指标变化对孕妇早产发生的影响研究(1)
摘要：目的 观察分析乙型肝炎病毒感染伴肝功能一样指标变化对孕妇早产发生的影响。方法 回顾性分析我院2015年2月～2016年2月收治的120例肝功能异常的乙肝孕妇临床资料，测定孕妇的TBIL(总胆红素)、ALT(丙氨酸氨基转移酶)、AST(冬氨酸氨基转移酶)、TBA(血清胆汁酸)。结果 对比早产孕妇和非早产孕妇的ALT、AST、TBA以及TBIL均数，早产组均高于非早产组，组间差异具有统计学意义(P<0.05)；当孕妇肝功发生异常，早产的发生率也随之提高，肝功中度以上的升高组，早产发生率显著高于轻度升高组，组间数据差异具有统计学意义(P<0.05)。结论 乙型肝炎病毒感染晚期妊娠血清中ALT、AST、TBA、TBIL水平与早产的发生率密切相关。
关键词：早产；肝功异常；乙型肝炎病毒
Research of Influence of Changes of Liver Function Indexes of Hepatitis B Virus Infection with Liver Function for Premature Birth of Pregnant Women
, http://www.100md.com
LUO Qiu-ling
(Jianli County People's Hospital，Jingzhou 433300，Hubei，China)
Abstract：Objective To observe and analyze the influence of hepatitis B virus infection with liver function index changes on the occurrence of preterm birth in pregnant women. Methods Clinical data of 120 cases of hepatitis B pregnant women with abnormal liver function and who accepted treatments in our hospital from February， 2015 to February， 2016 were retrospective analyzed，and the TBIL (total bilirubin)， ALT (alanine aminotransferase)， AST (alanine aminotransferase)， TBA (serum bile acid) of pregnant women were determined. Results The ALT， AST， TBA， and TBIL were compared between preterm and non preterm pregnant women， the preterm group was higher than that in the non preterm group and the difference was statistically significant (P<0.05)；When the abnormal liver function of pregnant women， the incidence of preterm birth is increased，and the liver function were more than moderate level group.The incidence of preterm labor was significantly higher than that in the mild group， the difference was statistically significant (P<0.05). Conclusion The levels of ALT， AST， TBA and TBIL in serum of patients with advanced hepatitis B virus infection are closely related to the incidence of premature labor.
, http://www.100md.com
Key words：Premature； Abnormal liver function； Hepatitis B virus
乙肝是临床常见病，指乙肝病毒检测为阳性，病程低于半年或发病日期不明的具有慢性肝炎表现的患者[1]。我国乙肝患者较多，而妊娠合并乙肝也是产科常见的疾病，妊娠合并乙肝会对母婴造成严重危害，隶属高危妊娠范畴，若肝脏受损情况严重，对母婴的危害也就越大，甚至可导致早产、死胎、新生儿死亡。为有效避免以上情況，加强妊娠合并乙肝孕妇的肝功检测，选择出能判断母婴预后的指标，为临床处理提供依据。基于此，本研究通过分析乙肝伴肝功能异常肝功指标对孕妇早产发生的影响，情况如下：
1 资料与方法
1.1一般资料 回顾性分析我院2015年2月～2016年2月收治的120例肝功能异常的乙肝孕妇临床资料，其中经产妇43例，初产妇77例，年龄23.5～34.5岁，平均(29.0±4.5)岁。
1.2方法 本次所用仪器选用日本HITACHI-7600型全自动生化分析仪，所用试剂均为本仪器匹配的专用试剂。取所有孕妇次日5 ml空腹静脉血，以3000 r/min的速度离心3 min，分离血清，检测TBIL、ALT、AST、TBA指标。按照妊娠结局将孕妇分为早产组(67例)和非早产组(53例)。
1.3评判标准 早产：孕龄<37。肝功异常范围[2]：ALT>40 u/L，TBIL>17.1 umol/L，AST>40 u/L，TBA>13 umol/L。, http://www.100md.com(罗秋玲)
关键词：早产；肝功异常；乙型肝炎病毒
Research of Influence of Changes of Liver Function Indexes of Hepatitis B Virus Infection with Liver Function for Premature Birth of Pregnant Women
, http://www.100md.com
LUO Qiu-ling
(Jianli County People's Hospital，Jingzhou 433300，Hubei，China)
Abstract：Objective To observe and analyze the influence of hepatitis B virus infection with liver function index changes on the occurrence of preterm birth in pregnant women. Methods Clinical data of 120 cases of hepatitis B pregnant women with abnormal liver function and who accepted treatments in our hospital from February， 2015 to February， 2016 were retrospective analyzed，and the TBIL (total bilirubin)， ALT (alanine aminotransferase)， AST (alanine aminotransferase)， TBA (serum bile acid) of pregnant women were determined. Results The ALT， AST， TBA， and TBIL were compared between preterm and non preterm pregnant women， the preterm group was higher than that in the non preterm group and the difference was statistically significant (P<0.05)；When the abnormal liver function of pregnant women， the incidence of preterm birth is increased，and the liver function were more than moderate level group.The incidence of preterm labor was significantly higher than that in the mild group， the difference was statistically significant (P<0.05). Conclusion The levels of ALT， AST， TBA and TBIL in serum of patients with advanced hepatitis B virus infection are closely related to the incidence of premature labor.
, http://www.100md.com
Key words：Premature； Abnormal liver function； Hepatitis B virus
乙肝是临床常见病，指乙肝病毒检测为阳性，病程低于半年或发病日期不明的具有慢性肝炎表现的患者[1]。我国乙肝患者较多，而妊娠合并乙肝也是产科常见的疾病，妊娠合并乙肝会对母婴造成严重危害，隶属高危妊娠范畴，若肝脏受损情况严重，对母婴的危害也就越大，甚至可导致早产、死胎、新生儿死亡。为有效避免以上情況，加强妊娠合并乙肝孕妇的肝功检测，选择出能判断母婴预后的指标，为临床处理提供依据。基于此，本研究通过分析乙肝伴肝功能异常肝功指标对孕妇早产发生的影响，情况如下：
1 资料与方法
1.1一般资料 回顾性分析我院2015年2月～2016年2月收治的120例肝功能异常的乙肝孕妇临床资料，其中经产妇43例，初产妇77例，年龄23.5～34.5岁，平均(29.0±4.5)岁。
1.2方法 本次所用仪器选用日本HITACHI-7600型全自动生化分析仪，所用试剂均为本仪器匹配的专用试剂。取所有孕妇次日5 ml空腹静脉血，以3000 r/min的速度离心3 min，分离血清，检测TBIL、ALT、AST、TBA指标。按照妊娠结局将孕妇分为早产组(67例)和非早产组(53例)。
1.3评判标准 早产：孕龄<37。肝功异常范围[2]：ALT>40 u/L，TBIL>17.1 umol/L，AST>40 u/L，TBA>13 umol/L。, http://www.100md.com(罗秋玲)
参见：首页 > 医疗版 > 疾病专题 > 妇产科 > 异常分娩 > 早产